FAM21C (WASHC2C) (NM_015262) Human Untagged Clone
CAT＃: SC102564
FAM21C (untagged)-Human family with sequence similarity 21, member C (FAM21C), transcript variant 1
CNY 9184.00
货期*
现货
规格
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Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | FAM21A; FAM21C; VPEF |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_015262, the custom clone sequence may differ by one or more nucleotides
ATGATGAACCGGACGACCCCCGACCAGGAGCTGGTGCCGGCGTCGGAGCCCGTGTGGGAGCGGCCGTGGT CGGTGGAGGAGATCCGCAGGAGCAGCCAGAGCTGGTCGCTGGCGGCCGACGCGGGCCTACTACAGTTTCT ACAGGAATTCTCACAGCAAACTATCTCTAGGACCCATGAAATCAAGAAACAAGTGGACGGACTAATCCGG GAAACCAAAGCCACAGATTGTCGCCTGCATAATGTCTTCAATGACTTCCTTATGCTCTCTAATACCCAGT TCATAGAGAATCGTGTATATGATGAAGAAGTGGAGGAGCCAGTACTCAAGGCTGAGGCAGAAAAAACAGA GCAGGAGAAGACACGAGAGCAGAAAGAAGTAGATCTCATTCCTAAAGTCCAGGAGGCTGTGAACTATGGC TTACAAGTATTGGACAGTGCCTTTGAGCAACTTGATATCAAAGCAGGAAACTCAGACTCCGAGGAAGATG ATGCTAATGGGCGGGTGGAACTGATCCTTGAACCAAAGGATCTATACATTGATCGTCCTTTACCATATCT CATTGGGTCAAAGCTGTTCATGGAACAAGAAGATGTAGGTCTTGGAGAGCTGTCCAGTGAAGAAGGCTCT GTAGGCAGTGATCGTGGCAGTATTGTGGACACTGAGGAAGAGAAAGAAGAGGAGGAGTCAGATGAAGATT TTGCCCATCACAGTGACAATGAACAAAACCAGCACACCACACAAATGAGTGATGAGGAAGAGGATGATGA TGGCTGTGACCTTTTTGCTGACTCTGAGAAGGAGGAGGAAGATATTGAGGACATTGAAGAAAATACTAGA CCTAAAAGAAGCAGACCTACATCGTTTGCAGATGAGCTGGCTGCCCGCATCAAGGGGGATGCCATGGGTC GAGTGGACGAGGAGCCGACAACCTTACCCTCAGGAGAAGCAAAACCTCGGAAGACACTCAAAGAGAAGAA GGAAAGGAGAACTCCTTCAGACGATGAAGAGGATAACTTATTCGCACCCCCCAAGCTGACCGACGAGGAC TTCTCGCCATTTGGCTCTGGAGGTGGCCTGTTCAGTGGCGGCAAGGGGCTATTTGATGATGAGGACGAGG AGAGTGACCTCTTCACGGAAGCCTCCCAGGATCGGCAAGCTGGAGCCTCTGTTAAGGAGGAGTCTTCATC ATCCAAACCTGGAAAGAAAATCCCAGCAGGAGCTGTTTCTGTATTTTTAGGAGACACGGATGTGTTTGGT GCTGCCTCCGTTCCATCACTGAAGGAGCCACAGAAGCCTGAGCAGCCCACTCCAAGGAAAAGCCCCTATG GTCCCCCTCCCACTGGCCTCTTTGATGATGATGATGGTGATGATGATGACGACTTTTTCTCGGCACCCCA CAGCAAACCTTCTAAAACACGCAAAGTCCAATCCACTGCCGATATCTTTGGTGACGAAGAAGGAGATCTG TTCAAAGAAAAAGCCGTAGCATCGCCAGAAGCCACTGTGAGTCAGACAGATGAAAATAAAGCAAGAGCAG AAAAAAAGGTTACCTTATCTTACAGCAAAAATCTCAAGCCCTCATCAGAAACAAAGACTCAAAAAGGCTT ATTTTCAGATGAGGAGGACTCTGAGGATTTGTTTTCTTCTCAAAGTGCGAGTAACTTAAAAGGTGCATCT CTGCTGCCTGGCAAGCTCCCCACGTCGGTTTCCCTGTTTGATGATGAAGATGAAGAGGATAATCTTTTTG GGGGTACAGCTGCTAAGAAGCAGACATTGTCTCTACAAGCTCAGAGAGAAGAGAAAGCAAAAGCCTCCGA GCTCTCCAAAAAGAAAGCATCTGCCCTGTTGTTCAGCAGTGATGAGGAGGACCAGTGGAATATTCCTGCT TCACAGACCCACTTAGCATCTGACAGCAGGTCTAAAGGAGAACCCAGGGATTCTGGGACCCTCCAGAGCC AGGAGGCCAAGGCTGTGAAAAAGACCAGTCTCTTTGAGGAAGACAAAGAAGATGATCTTTTTGCCATTGC CAAGGACAGCCAAAAGAAGACCCAGAGAGTGTCACTCCTCTTTGAAGACGATGTTGATAGCGGAGGCTCT CTGTTTGGCTCTCCTCCCACATCTGTTCCTCCTGCAACAAAGAAAAAAGAGACTGTCTCTGAGGCACCAC CTTTGCTGTTCAGCGATGAAGAAGAGAAGGAGGCACAACTTGGAGTGAAGTCTGTGGATAAGAAGGTTGA GAGTGCCAAGGAGTCATTAAAATTTGGGAGAACTGATGTGGCTGAGTCAGAAAAGGAAGGACTTTTGACT AGATCTGCTCAGGAAACAGTCAAGCATTCTGATTTATTTTCTTCATCATCCCCATGGGACAAAGGAACCA AGCCTAGAACCAAAACTGTTCTTAGCTTGTTTGATGAGGAAGAGGATAAAATGGAAGATCAAAACATTAT CCAGGCTCCACAGAAAGAAGTAGGAAAGGGCTGCGATCCTGATGCCCACCCCAAGAGCACAGGTGTCTTC CAGGATGAAGAGCTGCTTTTCAGCCACAAGCTCCAAAAGGACAATGACCCAGATGTTGACCTTTTTGCTG GCACCAAAAAAACCAAGCTGTTAGAGCCAAGTGTTGGGAGCCTGTTTGGGGATGATGAAGATGATGATCT TTTCAGCTCTGCCAAGTCCCAGCCTTTGGTACAAGAGAAAAAGAGAGTAGTGAAAAAAGACCACTCTGTT AACTCTTTCAAAAACCAGAAACATCCTGAATCCATTCAAGGTAGTAAAGAAAAAGGCATATGGAAGCCGG AAACACCTCAGGCAAATTTAGCGATCAACCCAGCGGCCTTGCTGCCCACAGCGGCTTCCCAGATCTCTGA AGTAAAGCCTGTTTTGCCAGAATTGGCTTTTCCTTCATCTGAACACAGAAGGAGCCACGGTCTGGAAAGT GTGCCTGTCCTTCCCGGGAGTGGGGAGGCCGGTGTGAGTTTTGATCTTCCAGCTCAGGCAGACACCTTAC ACAGTGCAAACAAGAGCCGTGTCAAGATGAGAGGGAAGCGTAGACCGCAGACCCGTGCAGCTAGGCGGCT GGCTGCTCAGGAGTCCAGCGAGGCTGAGGACATGAGCGTCCCCAGAGGACCCATTGCACAGTGGGCTGAT GGCGCCATTTCCCCAAATGGCCATCGGCCACAGCTCAGAGCAGCCAGTGGAGAAGACAGCACTGAGGAGG CCCTGGCAGCTGCCGCTGCACCTTGGGAAGGTGGTCCTGTGCCTGGAGTGGACACAAGCCCCTTTGCAAA GTCTCTGGGTCATTCCAGAGGGGAGGCTGACCTTTTTGATTCTGGGGACATTTTTTCCACGGGCACTGGA TCTCAGTCCGTGGAGAGAACAAAACCCAAGGCAAAGATAGCAGAGAATCCTGCCAACCCACCAGTGGGTG GTAAAGCAAAGAGCCCCATGTTTCCTGCTCTAGGCGAGGCCAGCAGTGATGATGATCTCTTTCAGTCTGC TAAACCAAAACCAGCAAAGAAAACAAATCCCTTTCCTCTCCTGGAAGATGAGGATGACCTCTTTACAGAT CAGAAAGTCAAGAAGAATGAGACAAAATCCAGTAGTCAGCAGGATGTCATATTAACAACACAAGATATTT TTGAGGATGATATATTTGCTACGGAAGCAATTAAACCCTCTCAGAAAACCAGAGAGAAGGAGAAAACATT GGAATCTAATTTATTTGATGATAACATTGATATCTTTGCTGACTTAACTGTAAAACCAAAAGAAAAGTCC AAAAAGAAAGTGGAAGCCAAGTCTATATTTGATGATGATATGGATGACATCTTCTCCACTGGTATCCAGG CTAAGACAACCAAACCAAAAAGCCGATCTGCACAGGCCGCACCTGAACCAAGATTTGAACACAAGGTGTC CAACATCTTTGATGATCCCCTGAATGCCTTTGGAGGCCAGTAG >OriGene 5' read for NM_015262 unedited
NGGTGTCGNATTTTGTATACGACTCCTATAGGGCGGCCGCGATTCGGCACGAGGCGGGGC TCTGCGGTCCTCGGCGTGTGCTGGCAGCCTCGGAGCCCACCGAGCCGGGCGGCTGGGATG ATGAACCGGACGACCCCCGACCAGGAGCTGGTGCCGGCGTCGGAGCCCGTGTGGGAGCGG CCGTGGTCGGTGGAGGAGATCCGCAGGAGCAGCCAGAGCTGGTCGCTGGCGGCCGACGCG GGCCTACTACAGTTTCTACAGGAATTCTCACAGCAAACTATCTCTAGGACCCATGAAATC AAGAAACAAGTGGACGGACTAATCCGGGAAACCAAAGCCACAGATTGTCGCCTGCATAAT GTCTTCAATGACTTCCTTATGCTCTCTAATACCCAGTTCATAGAGAATCGTGTATATGAT GAAGAAGTGGAGGAGCCAGTACTCAAGGCTGAGGCAGAAAAAAACAGAGCAGGAGAAGAC ACGAGAGCAGAAAGAAGTAGATCTCATTCCTAAAGTCCAGGAGGCTGTGAACTATGGCTT ACAAGTATTGGACAGTGCCTTTGAGCAACTTGATATCAAAGCAGGAAACTCAGACTCCGA GGAAGATGATGCTAATGGGCGGGTGGAACTGATCCTTGAACCAAAGGATCTATACATTGA TCGTCCTTTACCATATCTCATTGNGTCAAAGCTGTTCATGGAACAAGAAGATGTANGTCT TGGAGAGCTGTCCAGTGAAGAAGGCTCTGTNAGCAGTGATCGTGGCAGTATTGTGGACAC TTGAGNNAGAGAAGAAGAGGAGGAGTCAGATGAAGATTTTGCCCATTCACAGTGACATGN NACANACCAGCACACCACACANATGAGTGATGAGGAAANAGATGATGATGGCTGTGACCT TTTTGCTGACTCTTGAAAAGAC >OriGene 3' read for NM_015262 unedited
NATCTATGNNACCGCGGCCGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGGGTTCC AATAAAATTTTATTAACAAAATATGACAGTGGGGGGGCCACAGTTTGCCAAACTTTGCCT TGGAGGACATGCAGAGGCACCCTCAGAATTCAGTGAAAACCTGCTCCCATATTGCTAAGA CTCATGAAGTATAATCTCTCATCTTCTTTCTCTTTCCCCTGCCCAAGCCCTAAGTTAGGG TTCCCATCCATATAACAAAGACTTCTGGTCAGGTGGCATTTGCTATCTCTGAGATTCCCT GCCCATGAAAGCCACAAAGAGATTTCTTCTTTTACACACCCTGAAGCATATTATGGCCCC AGCAAGGCTAACTAAATCAAACTGTGGTTTAAAAACAAAACAAACCAACCACTGTGAAAT ATTTATTTTTGTTTTGTAGTATTAAGCATGATTAAACCAGTGCAGAAAAATACCAAGTAC ATTGGGTGAACGATGAGCTAGCTGTTCTAGTATTTGCTTTTTGTAATCCAGTTAAGACCA TCAGCATATACAACATCATCACTAACTCAACAATGTAGCTGCAGGGTAACATGTGGATAC CCTGTGTGCTCTACTGGCCTCCAAAGGCATTCAGGGGATCATCAAAGATGTTGGACACCT TGTGTTCAAATCTTGGTTCAGGTGCGGCCTGTGCAGATCGGCTTTTTGGTTTGGTTGTCT TAACCTGGATACAGAGGAGAAGATGTCATCCATATCATCATCAATATAGACTTGGCTTTC CACTTCTTTTGGGACTTTCTTTTGGTTTAAGNTAAGTCAGCAAGATATCATGTTATCATC AAATAATTAGATTCCAGGGTTTCTTCTTCTCTCTGGTTTCCTGGAAGGGTTNATNGCCTT CGTACAAATTAATCATCTCAAAATATCTGGGGTGTTATTGGACT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_015262 |
| Insert Size | 4700 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_015262.1, NP_056077.1 |
| RefSeq Size | 4654 bp |
| RefSeq ORF | 3957 bp |
| Locus ID | 253725 |
| UniProt ID | Q9Y4E1 |
| Gene Summary | Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission (PubMed:19922874, PubMed:20498093, PubMed:22513087, PubMed:23331060). Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35 (PubMed:24980502). Required for the endosomal recruitment of CCC and retriever complexes subunits COMMD1 and CCDC93 as well as the retrievere complex subunit VPS35L (PubMed:25355947, PubMed:28892079).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC212130 | FAM21C (Myc-DDK-tagged)-Human family with sequence similarity 21, member C (FAM21C), transcript variant 1 |
CNY 13210.00 |
|
| RC212130L3 | Lenti-ORF clone of FAM21C (Myc-DDK-tagged)-Human family with sequence similarity 21, member C (FAM21C), transcript variant 1 |
CNY 15110.00 |
|
| RC212130L4 | Lenti-ORF clone of FAM21C (mGFP-tagged)-Human family with sequence similarity 21, member C (FAM21C), transcript variant 1 |
CNY 15110.00 |
|
| RG212130 | FAM21C (tGFP-tagged) - Human family with sequence similarity 21, member C (FAM21C), transcript variant 1 |
CNY 14540.00 |
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