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SOCS2 (NM_003877) Human Untagged Clone
CAT＃: SC108265
SOCS2 (untagged)-Human suppressor of cytokine signaling 2 (SOCS2)
CNY 2,400.00
CNY 2,950.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF within SC108265 sequence for NM_003877 edited (data generated by NextGen Sequencing)
ATGACCCTGCGGTGCCTTGAGCCCTCCGGGAATGGCGGGGAAGGGACGCGGAGCCAGTGG GGGACCGCGGGGTCGGCGGAGGAGCCATCCCCGCAGGCGGCGCGTCTGGCGAAGGCCCTG CGGGAGCTCGGTCAGACAGGATGGTACTGGGGAAGTATGACTGTTAATGAAGCCAAAGAG AAATTAAAAGAGGCACCAGAAGGAACTTTCTTGATTAGAGATAGCTCGCATTCAGACTAC CTACTAACAATATCTGTTAAAACATCAGCTGGACCAACTAATCTTCGAATCGAATACCAA GACGGAAAATTCAGATTGGACTCTATCATATGTGTCAAATCCAAGCTTAAACAATTTGAC AGTGTGGTTCATCTGATCGACTACTATGTTCAGATGTGCAAGGATAAGCGGACAGGTCCA GAAGCCCCCCGGAACGGCACTGTTCACCTTTATCTGACCAAACCGCTCTACACGTCAGCA CCATCTCTGCAGCATCTCTGTAGGCTCACCATTAACAAATGTACCGGTGCCATCTGGGGA CTGCCTTTACCAACAAGACTAAAAGATTACTTGGAAGAATATAAATTCCAGGTATAA Clone variation with respect to NM_003877.3 >OriGene 5' read for NM_003877 unedited
TTCAAATTTGTATACGACTCCTATAGGGCGGCCGCGAATTCGCACGAGGTTTAACTCTTG CCAAGTCTCGTCGCAGCCGCCGCGGCTGGCGGGCCTTGGGCTTCCCCTGAAGCATGAGCC CTCTCGCCCGCAGCCACCCTCACCGCGTGGCCCGCGGACAGTGCGCGCCGGGGTCCCGGG TGCACAGCCTCAGGATACCCCGTGCCCGCAGCTCGGGCGCCCGCGGCAGGCGATCAGTGG GTGACCGCGGCTGCGAGGGACTTTGTCATCCGTCCTCCAGGATCTGGGGAGAAAGAGCCC CATCCCTTCTCTCTCTGCCACCATTTCGGACACCCCGCAGGGACTCGTTTTGGGATTCGC ACTGACTTCAAGGAAGGACGCGAACCCTTCTCTGACCCCAGCTCGGGCGGCCACCTGTCT TTGCCGCGGTGACCCTTCTCTCATGACCCTGCGGTGCCTTGAGCCCTCCGGGAATGGCGG GGAAGGGACGCGGAGCCAGTGGGGGACCGCGGGGTCGGCGGAGGAGCCATCCCCGCAGGC GGCGCGTCTGGCGAAGGCCCTGCGGGAGCTCGGTCAGACAGGATGGTACTGGGGAAGTAT GACTGTTAATGAAGCCAAAGAGAAATTAAAAGAGGCACCAGAAGGAACTTTCTTGATTAG AGATAGCTCGCATTCAGACTACCTACTAACAATATCTGTTAAAACATCAGCTGGACCAAC TAATCTTCGAATCGAATACCAAGACGGAAAATTCAGATTGGACTCTATCATATGTGTCAA ATCCAAGCTTAAACATNTGACAGTGTGGGTCATCTGATCACTACTATGTTCAGATGTGCA AGGATAAGGGGACAGGTNCAGAAGCCCCCGGAACGGCACTGGTCACCTTNTCTGACCCAA CGCTCTAACGTNAGCACATCTCTGAGCATCTCTGTAGGCTACATTACAAAGTTACCGTGC ATCTTGGGGGACTNCTTTACACAGAAT >OriGene 3' read for NM_003877 unedited
AGCCCGCATTTTAGNATCGAGTTTTTTTTTTTTTTTTTTAAAAATAGGTTTTTTTTATTT AATACATTCTAATCAAATAGTAACAGCAGTAAATAAACACTTTGAAAAACAGGCAGGTAT CCCCCTGTATCTGGAAGAAAATTAAGTCAAAGTATTCTACACAGTAGAAGGGAGACAACT GTTTATGTCCATGGTTAGACAATTCAAGGACAACTTGGATATTTCTAAAGCCATTTCCAA AAAATCAATGGCAACAGGTTGGGACACAGCTATTTCAAAGGGTAGAATGCCTATACCTAC ATTGGTTTTTATTAACGGGGATTGAGTTGCACCTGTATAGCATGATATTCTTGTCTTTAG CTTTAAAGGAAAAGAGAAAGTCTTTTCCATTTGCACCAGTTTGAAATATTTCTGAAATAA GGCTCCCATAGAATGGATTACTACAGTACTCATTCACATGAGAGTTCCTACATGTAGTAA AAAGACAAATACAGGACTTCATGGTCACTTTTTTTGGTTGATTTGGTTAATTGCATAAAA TGGGATAAATACTCACATACATCATCTGTTTAACAAAACTCCTAGGTACATCAGAATGCA AAATATAAAATGCCCAAGAGACTCTGATCAGCAGGCATATCAAATTGCAGTGAGGCCTGT GTCAGCTTGGTTCCTTCCCACTTCTTCAGTATTCCTATGANGAGTTCTTTCTCTCCTACT GGAGCCTGGACCTTTGACATAATGGAAAAGAACCTAAGAAAGCAAGGCATTCTGATAAAA CGCGACTTCAGCCTTTACATGCGACATTNTATTTTTAATCTAANAGGATCACACAGTCTT GGCCAGCCTTTAGACGGAAACATCACTCAGGTAAAAGTATCTGGAGGAACTTTAACCACT TACTACCTCTTCAAGCCTGTTAATTCAAATAGATTACCTTCAGCTGTTCTTAGAAGCATT CCTTATGNTTCCACACACTCAGTTTT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003877 |
| Insert Size | 1960 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_003877.3, NP_003868.1 |
| RefSeq Size | 2210 bp |
| RefSeq ORF | 597 bp |
| Locus ID | 8835 |
| UniProt ID | O14508 |
| Domains | SH2, SOCS |
| Protein Families | Druggable Genome |
| Protein Pathways | Insulin signaling pathway, Jak-STAT signaling pathway, Type II diabetes mellitus |
| Gene Summary | This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
MicroRNA-194 Promotes Prostate Cancer Metastasis by Inhibiting SOCS2
,Das, R;Gregory, PA;Fernandes, RC;Denis, I;Wang, Q;Townley, SL;Zhao, SG;Hanson, AR;Pickering, MA;Armstrong, HK;Lokman, NA;Ebrahimie, E;Davicioni, E;Jenkins, RB;Karnes, RJ;Ross, AE;Den, RB;Klein, EA;Chi, KN;Ramshaw, HS;Williams, ED;Zoubeidi, A;Goodall, GJ;Feng, FY;Butler, LM;Tilley, WD;Selth, LA;,
Cancer Res
,PubMed ID 28011622
[SOCS2]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203163 | SOCS2 (Myc-DDK-tagged)-Human suppressor of cytokine signaling 2 (SOCS2) |
CNY 2,400.00 |
|
| RC203163L1 | Lenti ORF clone of Human suppressor of cytokine signaling 2 (SOCS2), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC203163L2 | Lenti ORF clone of Human suppressor of cytokine signaling 2 (SOCS2), mGFP tagged |
CNY 5,890.00 |
|
| RC203163L3 | Lenti ORF clone of Human suppressor of cytokine signaling 2 (SOCS2), Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC203163L4 | Lenti ORF clone of Human suppressor of cytokine signaling 2 (SOCS2), mGFP tagged |
CNY 4,800.00 |
|
| RG203163 | SOCS2 (tGFP-tagged) - Human suppressor of cytokine signaling 2 (SOCS2) |
CNY 4,000.00 |
|
| SC320892 | SOCS2 (untagged)-Human suppressor of cytokine signaling 2 (SOCS2) |
CNY 2,400.00 |
