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Von Hippel Lindau (VHL) (NM_000551) Human Untagged Clone
CAT＃: SC109881
VHL (untagged)-Human von Hippel-Lindau tumor suppressor (VHL), transcript variant 1
CNY 2,400.00
CNY 3,990.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HRCA1; pVHL; RCA1; VHL1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_000551 edited
ATGCCCCGGAGGGCGGAGAACTGGGACGAGGCCGAGGTAGGCGCGGAGGAGGCAGGCGTC GAAGAGTACGGCCCTGAAGAAGACGGCGGGGAGGAGTCGGGCGCCGAGGAGTCCGGCCCG GAAGAGTCCGGCCCGGAGGAACTGGGCGCCGAGGAGGAGATGGAGGCCGGGCGGCCGCGG CCCGTGCTGCGCTCGGTGAACTCGCGCGAGCCCTCCCAGGTCATCTTCTGCAATCGCAGT CCGCGCGTCGTGCTGCCCGTATGGCTCAACTTCGACGGCGAGCCGCAGCCCTACCCAACG CTGCCGCCTGGCACGGGCCGCCGCATCCACAGCTACCGAGGTCACCTTTGGCTCTTCAGA GATGCAGGGACACACGATGGGCTTCTGGTTAACCAAACTGAATTATTTGTGCCATCTCTC AATGTTGACGGACAGCCTATTTTTGCCAATATCACACTGCCAGTGTATACTCTGAAAGAG CGATGCCTCCAGGTTGTCCGGAGCCTAGTCAAGCCTGAGAATTACAGGAGACTGGACATC GTCAGGTCGCTCTACGAAGATCTGGAAGACCACCCAAATGTGCAGAAAGACCTGGAGCGG CTGACACAGGAGCGCATTGCACATCAACGGATGGGAGATTGA >OriGene 5' read for NM_000551 unedited
GGCTCAGATTGTAAACGACTTACTGTGGGCGGCAAAGCCCTTCGCACGAGCCTCGTGCCT ATTTCGGCACGAGGCCGCGGCGTCCCGCCCGGGTGGTCTGGATCGCGGAGGGAATGCCCC GGAGGGCGGACAACTGGGACGAGGCCGAGGTAAGCGCGGAGGAGGCAGGCGTCGAAGAGT ACGGCCCTGCAACAAGACGGCGGGGAGGAGTTGTTTTTCTGACGAGTCCGGCCCGGAAGA GTCCGGCCCGGAGGAACTGGGCGCCGAGGAGGATATGGAGGCCGGGCGGCCGCGGCCCGT GCTGCGCTCGGTGAACTCGCGCGAGCCCTCCCAGGTCATCTTCTGCAATCGCAGTCCGCG CGTCGTGCTGCCCGTATGGCTCAACTTCGACGGCGAGCCGCAGCCCTACCCAACGCTGCC GCCTGGCACGGGCCGCCGCATCCACAGCTACCGAGGTCACCTTTGGCTCTTCAAAGATGC AGGGACACACGATGGGCTTCTGGTTAACCAAACTGAATTATTTGTGCCATCTCTCAATGT TGACGGACAGCCTATTTTTGCCAATATCACACTGCCAGTGTATACTCTGAAAGAGCGATG CCTCCAGGTTGTCCGGAGCCTAGTCAAGCCTGAGAATTACAGGAGACTGGACATCGTCAG GTCGCTCTACGAAGATCTGGAAGACCACCCATATGTGCAGAAAGACCTGGAGCGGCTGAC ACAGGAGCGCATTGCACATCACCGGATGGGAGATTGAAGATTTCTGTTGAAACTTACACT GGTTCATCTCAACTTTTGATGGGACTGGTGAGTCTTGATCTAGATACAGGACTGGGTTCT TTCTTAAGTTTCAAAGGGTCTCATTCTCAGAGTTAAATAGGCCCCATTGCTTAAAAGGAA ATTAACGGCCTTCCCTAGG >OriGene 3' read for NM_000551 unedited
CCGCGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTGAGGCAGGGTCTTGCCCT GTCCCCCAGGCTGGAGTGCAGTGGCATACTCATGGCTCACTGCCGCCTCCAATTCCTAAA CTCCAATGATCTTCTCACCTCAGCCTGCCAAGTAGCTAGGATTACAGATGTGTGCCGCCA TGCTAATTTTTAAAAATTTTTTGTATAGATGGGTTCTCACTATGAGCCCAGGCTCATCTT GAAGTTCTGGGCTCAAGCAATCCTCTCACCTTGGCTTCCCAAAGTACTGGGATTACAGGC GGGAGCCACCATGCCAGCCGTCACTCTCATTTTTGAGCACAGGAATTGTGCCCAAAGGCT AGGATAAGGAATTAAAGATGCATGCCAAGAAATACCCACAAACATTAATTATAAAAGGGA GACTATACTAATGTTTGTGAAAAGCTTATACTAACATAGAGCAATATTTAAGTTATAAAG TTAAATGAAAAAGGGTATAAAACTGTATGAACAGTACAATCTCAACTATGTAAAAACCAA CCAAAATCTGCCCTAAAAAGGCTGGAAGGAAATAGCTCAAAATGTTAATGTGATTGTATT TAAGAAGTGTATCTAATAGGGATCTTTTTTCTTCCTTTTTAGCTCTCTGCCCTTTCCAAA TGTTTCTCTACTGGGGAGATTTTTTTAAAAAGCTCTTAGGGAAGGAGTACCAACCAAAGT GGAAAAAAAAATCTATTATTTACCAAAAACTGAGTCTGAAAAAACCATTGAATTTGAGGT CATGACTCCAAGTCTACCCTTAAAGAATTTGCGCATCTATAAACCTTGGAACCGTCCCGC TTCCTCATGAATCTCTGTTAGACCAAAGCTGAAGTGGAACGCCCCTGGCCTGCTGAAAAA AAGCTGATAGCCGGCCGGGGCCCCACCCGGTTCCCCCTTTCGGAGCTGG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000551 |
| Insert Size | 2620 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000551.2, NP_000542.1 |
| RefSeq Size | 2968 bp |
| RefSeq ORF | 642 bp |
| Locus ID | 7428 |
| UniProt ID | P40337 |
| Domains | VHL |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Pathways in cancer, Renal cell carcinoma, Ubiquitin mediated proteolysis |
| Gene Summary | Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC216151 | VHL (Myc-DDK-tagged)-Human von Hippel-Lindau tumor suppressor (VHL), transcript variant 1 |
CNY 2,400.00 |
|
| RC216151L1 | Lenti ORF clone of Human von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC216151L2 | Lenti ORF clone of Human von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC216151L3 | Lenti ORF clone of Human von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, Myc-DDK-tagged |
CNY 4,800.00 |
|
| RC216151L4 | Lenti ORF clone of Human von Hippel-Lindau tumor suppressor (VHL), transcript variant 1, mGFP tagged |
CNY 4,800.00 |
|
| RG216151 | VHL (tGFP-tagged) - Human von Hippel-Lindau tumor suppressor (VHL), transcript variant 1 |
CNY 4,000.00 |
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