TLR7 (NM_016562) Human Untagged Clone
CAT＃: SC114214
TLR7 (untagged)-Human toll-like receptor 7 (TLR7)
CNY 7312.00
| Cited in 1 publication. |
Product images
热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | IMD74; TLR7-like |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_016562 edited
GAATTCGGCACGAGGCCAGATATAGGATCACTCCATGCCATCAAGAAAGTTGATGCTATT GGGCCCATCTCAAGCTGATCTTGGCACCTCTCATGCTCTGCTCTCTTCAACCAGACCTCT ACATTCCATTTTGGAAGAAGACTAAAAATGGTGTTTCCAATGTGGACACTGAAGAGACAA ATTCTTATCCTTTTTAACATAATCCTAATTTCCAAACTCCTTGGGGCTAGATGGTTTCCT AAAACTCTGCCCTGTGATGTCACTCTGGATGTTCCAAAGAACCATGTGATCGTGGACTGC ACAGACAAGCATTTGACAGAAATTCCTGGAGGTATTCCCACGAACACCACGAACCTCACC CTCACCATTAACCACATACCAGACATCTCCCCAGCGTCCTTTCACAGACTGGACCATCTG GTAGAGATCGATTTCAGATGCAACTGTGTACCTATTCCACTGGGGTCAAAAAACAACATG TGCATCAAGAGGCTGCAGATTAAACCCAGAAGCTTTAGTGGACTCACTTATTTAAAATCC CTTTACCTGGATGGAAACCAGCTACTAGAGATACCGCAGGGCCTCCCGCCTAGCTTACAG CTTCTCAGCCTTGAGGCCAACAACATCTTTTCCATCAGAAAAGAGAATCTAACAGAACTG GCCAACATAGAAATACTCTACCTGGGCCAAAACTGTTATTATCGAAATCCTTGTTATGTT TCATATTCAATAGAGAAAGATGCCTTCCTAAACTTGACAAAGTTAAAAGTGCTCTCCCTG AAAGATAACAATGTCACAGCCGTCCCTACTGTTTTGCCATCTACTTTAACAGAACTATAT CTCTACAACAACATGATTGCAAAAATCCAAGAAGATGATTTTAATAACCTCAACCAATTA CAAATTCTTGACCTAAGTGGAAATTGCCCTCGTTGTTATAATGCCCCATTTCCTTGTGCG CCGTGTAAAAATAATTCTCCCCTACAGATCCCTGTAAATGCTTTTGATGCGCTGACAGAA TTAAAAGTTTTACGTCTACACAGTAACTCTCTTCAGCATGTGCCCCCAAGATGGTTTAAG AACATCAACAAACTCCAGGAACTGGATCTGTCCCAAAACTTCTTGGCCAAAGAAATTGGG GATGCTAAATTTCTGCATTTTCTCCCCAGCCTCATCCAATTGGATCTGTCTTTCAATTTT GAACTTCAGGTCTATCGTGCATCTATGAATCTATCACAAGCATTTTCTTCACTGAAAAGC CTGAAAATTCTGCGGATCAGAGGATATGTCTTTAAAGAGTTGAAAAGCTTTAACCTCTCG CCATTACATAATCTTCAAAATCTTGAAGTTCTTGATCTTGGCACTAACTTTATAAAAATT GCTAACCTCAGCATGTTTAAACAATTTAAAAGACTGAAAGTCATAGATCTTTCAGTGAAT AAAATATCACCTTCAGGAGATTCAAGTGAAGTTGGCTTCTGCTCAAATGCCAGAACTTCT GTAGAAAGTTATGAACCCCAGGTCCTGGAACAATTACATTATTTCAGATATGATAAGTAT GCAAGGAGTTGCAGATTCAAAAACAAAGAGGCTTCTTTCATGTCTGTTAATGAAAGCTGC TACAAGTATGGGCAGACCTTGGATCTAAGTAAAAATAGTATATTTTTTGTCAAGTCCTCT GATTTTCAGCATCTTTCTTTCCTCAAATGCCTGAATCTGTCAGGAAATCTCATTAGCCAA ACTCTTAATGGCAGTGAATTCCAACCTTTAGCAGAGCTGAGATATTTGGACTTCTCCAAC AACCGGCTTGATTTACTCCATTCAACAGCATTTGAAGAGCTTCACAAACTGGAAGTTCTG GATATAAGCAGTAATAGCCATTATTTTCAATCAGAAGGAATTACTCATATGCTAAACTTT ACCAAGAACCTAAAGGTTCTGCAGAAACTGATGATGAACGACAATGACATCTCTTCCTCC ACCAGCAGGACCATGGAGAGTGAGTCTCTTAGAACTCTGGAATTCAGAGGAAATCACTTA GATGTTTTATGGAGAGAAGGTGATAACAGATACTTACAATTATTCAAGAATCTGCTAAAA TTAGAGGAATTAGACATCTCTAAAAATTCCCTAAGTTTCTTGCCTTCTGGAGTTTTTGAT GGTATGCCTCCAAATCTAAAGAATCTCTCTTTGGCCAAAAATGGGCTCAAATCTTTCAGT TGGAAGAAACTCCAGTGTCTAAAGAACCTGGAAACTTTGGACCTCAGCCACAACCAACTG ACCACTGTCCCTGAGAGATTATCCAACTGTTCCAGAAGCCTCAAGAATCTGATTCTTAAG AATAATCAAATCAGGAGTCTGACGAAGTATTTTCTACAAGATGCCTTCCAGTTGCGATAT CTGGATCTCAGCTCAAATAAAATCCAGATGATCCAAAAGACCAGCTTCCCAGAAAATGTC CTCAACAATCTGAAGATGTTGCTTTTGCATCATAATCGGTTTCTGTGCACCTGTGATGCT GTGTGGTTTGTCTGGTGGGTTAACCATACGGAGGTGACTATTCCTTACCTGGCCACAGAT GTGACTTGTGTGGGGCCAGGAGCACACAAGGGCCAAAGTGTGATCTCCCTGGATCTGTAC ACCTGTGAGTTAGATCTGACTAACCTGATTCTGTTCTCACTTTCCATATCTGTATCTCTC TTTCTCATGGTGATGATGACAGCAAGTCACCTCTATTTCTGGGATGTGTGGTATATTTAC CATTTCTGTAAGGCCAAGATAAAGGGGTATCAGCGTCTAATATCACCAGACTGTTGCTAT GATGCTTTTATTGTGTATGACACTAAAGACCCAGCTGTGACCGAGTGGGTTTTGGCTGAG CTGGTGGCCAAACTGGAAGACCCAAGAGAGAAACATTTTAATTTATGTCTCGAGGAAAGG GACTGGTTACCAGGGCAGCCAGTTCTGGAAAACCTTTCCCAGAGCATACAGCTTAGCAAA AAGACAGTGTTTGTGATGACAGACAAGTATGCAAAGACTGAAAATTTTAAGATAGCATTT TACTTGTCCCATCAGAGGCTCATGGATGAAAAAGTTGATGTGATTATCTTGATATTTCTT GAGAAGCCCTTTCAGAAGTCCAAGTTCCTCCAGCTCCGGAAAAGGCTCTGTGGGAGTTCT GTCCTTGAGTGGCCAACAAACCCGCAAGCTCACCCATACTTCTGGCAGTGTCTAAAGAAC GCCCTGGCCACAGACAATCATGTGGCCTATAGTCAGGTGTTCAAGGAAACGGTCTAGCCC TTCTTTGCAAAACACAACTGCCTAGTTTACCAAGGAGAGGCCTGGCTGTTTAAATTGTTT TCATATATATCACACCAAAAGCGTGTTTTGAAATTCTTCAAGAAATGAGATTGCCCATAT TTCAGGGGAGCCACCAACGTCTGTCACAGGAGTTGGAAAGATGGGGTTTATATAATGCAT CAAGTCTTCTTTCTTATCTCTCTGTGTCTCTATTTGCACTTGAGTCTCTCACCTCAGCTC CTGTAAAAGAGTGGCAAGTAAAAAACATGGGGCTCTGATTCTCCTGTAATTGTGATAATT AAATATACACACAATCATGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_016562 unedited
GTAAGATAGAATTGTATACCACTCATATAGGCGGCCGACGAATTCGCACGAGGCCAGNAA TAGGATCACTCCATGCCATCAAGAAAGTTGATGCTATTGGGCCCATCTCAAGCTGATCTT GGCACCTCTCATGCTCTGCTCTCTTCAACCAGACCTCTACATTCCATTTTGGAAGAAGAC TAAAAATGGTGTTTCCAATGTGGACACTGAAGAGACAAATTCTTATCCTTTTTAACATAA TCCTAATTTCCAAACTCCTTGGGGCTAGATGGTTTCCTAAAACTCTGCCCTGTGATGTCA CTCTGGATGTTCCAAAGAACCATGTGATCGTGGACTGCACAGACAAGCATTTGACAGAAA TTCCTGGAGGTATTCCCACGAACACCACGAACCTCACCCTCACCATTAACCACATACCAG ACATCTCCCCAGCGTCCTTTCACAGACTGGACCATCTGGTAGAGATCGATTTCAGATGCA ACTGTGTACCTATTCCACTGGGGTCAAAAAACAACATGTGCATCAAGAGGCTGCAGATTA AACCCAGAAGCTTTAGTGGACTCACTTATTTAAAATCCCTTTACCTGGATGGAAACCAGC TACTAGAGATACCGCAGGGCCTCCCGCCTAGCTTACAGCTTCTCAGCCTTGAGGCCAACA ACATCTTTTCCATCAGAAAAGAGAATCTAACAGAACTGGCCAACATAGAAATACTCTACC TGGGCCAAAACTGTTATTATCGAAATCCCTTGTTATGTTCATATTCAATAGAGAAAGATG CCTTTCCTAACTTGACAAGTTAAAAGTGCTCTCCCTGAAAGATAACATGTCACAGCCGTC CCTACTGNTTTGCCATCTACTTAAACAGAACTATATCTCTACACAACATGATTTGCAAAT CCAGC >OriGene 3' read for NM_016562 unedited
GGTGTATTTTATTTTACATTACAGGNANATCAGAGCCCCTGTTTTTTACTTGCCACTCTT TTACAGGAGCTGAGGTGAGAGACTCAAGTGCAAATAGAGACACAGAGAGATAAGAAAGAA GACTTGATGCATTATATAAACCCCATCTTTCCAACTCCTGTGACAGACGTTGGTGGCTCC CCTGAAATATGGGCAATCTCATTTCTTGAAGAATTTCAAAACACGCTTTTGGTGTGATAT ATATGAAAACAATTTAAACAGCCAGGCCTCTCCTTGGTAAACTAGGCAGTTGTGTTTTGC AAAGAAGGGCTAGACCGTTTCCTTGAACACCTGACTATAGGCCACATGATTGTCTGTGGC CAGGGCGTTCTTTAGACACTGCCAGAAGTATGGGTGAGCTCGCGGGTTTGTTGGCCACTC AAGGACAGAACTCTCACATAGCCTTTTCCGGAGCTGGAGGAACTTGGACTTCTGAAAGGG CTTCTCAAGTAATATCNNCCCCATCCATTAACTTTTTCATCCCTGACCCTCTGATGGCAC ATGTTAAACGCTTTCTTAAAATATTTACTCTTCGCATACTCGTCTGTCATTACAACCCTG TCTTCATCGTNAACGCATGCTTTCGGCATGGCCTCCCACACCTGGCTTCCCTAGTTACCA GCTCCCTTCTTTCCAGACTCAATTCATTGCTNNCATACCTGCGCCCTCCCCTTCGCCCCC CTTGCATACATATCCCACTCCCCCTCCCCTCCTCCTTGTAGCCTCCCCGTCACCACATTC CCCTTTNCTCCAGCCCTGCGATTTACATTCGCGCAACCTATTTTATTTTGCCCTTTGTAC TCTTTACAGTAGCCCCATCTCTNAAACGCAGCCCTTTAGTTAACACCTGACNNTTCCNCC GTCCTCCCTCTCTTCCCCTCGCTTGTCTCTTCGCTNCCTCCCTCCCCGCCAATGTTCTTC TTTTCGCTCGCCTTTCCCCCTTTC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_016562 |
| Insert Size | 3630 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_016562.3, NP_057646.1 |
| RefSeq Size | 4992 bp |
| RefSeq ORF | 3150 bp |
| Locus ID | 51284 |
| UniProt ID | Q9NYK1 |
| Domains | TIR, LRRCT, LRR, LRR_TYP, LRR_SD22, LRR_BAC |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Toll-like receptor signaling pathway |
| Gene Summary | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Aug 2020] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Novel Small Molecule Inhibitors of TLR7 and TLR9: Mechanism of Action and Efficacy In Vivo
,Lamphier, M;Zheng, W;Latz, E;Spyvee, M;Hansen, H;Rose, J;Genest, M;Yang, H;Shaffer, C;Zhao, Y;Shen, Y;Liu, C;Liu, D;Mempel, TR;Rowbottom, C;Chow, J;Twine, NC;Yu, M;Gusovsky, F;Ishizaka, ST;,
Mol. Pharmacol., Jan 2014.
,PubMed ID 24342772
[TLR7]
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| RC207515L1 | Lenti ORF clone of Human toll-like receptor 7 (TLR7), Myc-DDK-tagged |
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| RC207515L2 | Lenti ORF clone of Human toll-like receptor 7 (TLR7), mGFP tagged |
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| RC207515L3 | Lenti ORF clone of Human toll-like receptor 7 (TLR7), Myc-DDK-tagged |
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| RC207515L4 | Lenti ORF clone of Human toll-like receptor 7 (TLR7), mGFP tagged |
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| RG207515 | TLR7 (tGFP-tagged) - Human toll-like receptor 7 (TLR7) |
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