Cofilin 1 (CFL1) (NM_005507) Human Untagged Clone
CAT＃: SC116694
CFL1 (untagged)-Human cofilin 1 (non-muscle) (CFL1)
CNY 2400.00
CNY 2950.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CFL; cofilin; HEL-S-15 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_005507 edited
GAATTCGGCACGAGGCTGCAGCGCTCTCGTCTTCTGCGGCTCTCGGTGCCCTCTCCTTTT CGTTTCCGGAAACATGGCCTCCGGTGTGGCTGTCTCTGATGGTGTCATCAAGGTGTTCAA CGACATGAAGGTGCGTAAGTCTTCAACGCCAGAGGAGGTGAAGAAGCGCAAGAAGGCGGT GCTCTTCTGCCTGAGTGAGGACAAGAAGAACATCATCCTGGAGGAGGGCAAGGAGATCCT GGTGGGCGATGTGGGCCAGACTGTCGACGATCCCTACGCCACCTTTGTCAAGATGCTGCC AGATAAGGACTGCCGCTATGCCCTCTATGATGCAACCTATGAGACCAAGGAGAGCAAGAA GGAGGATCTGGTGTTTATCTTCTGGGCCCCCGAGTCTGCGCCCCTTAAGAGCAAAATGAT TTATGCCAGCTCCAAGGACGCCATCAAGAAGAAGCTGACAGGGATCAAGCATGAATTGCA AGCAAACTGCTACGAGGAGGTCAAGGACCGCTGCACCCTGGCAGAGAAGCTGGGGGGCAG TGCCGTCATCTCCCTGGAGGGCAAGCCTTTGTGAGCCCCTTCTGGCCCCCTGCCTGGAGC ATCTGGCAGCCCCACACCTGCCCTTGGGGGTTGCAGGCTGCCCCCTTCCTGCCAGACCGG AGGGGCTGGGGGGATCCCAGCAGGGGGAGGGCAATCCCTTCACCCCAGTTGCCAAACAGA CCCCCCACCCCCTGGATTTTCCTTCTCCCTCCATCCCTTGACGGTTCTGGCCTTCCCAAA CTGCTTTTGATCTTTTGATTCCTCTTGGGCTGAAGCAGACCAAGTTCCCCCCAGGCACCC CAGTTGTGGGGGAGCCTGTATTTTTTTTAACAACATCCCCATTCCCCACCTGGTCCTCCC CCTTCCCATGCTGCCAACTTCTAACCGCAATAGTGACTCTGTGCTTGTCTGTTTAGTTCT GTGTATAAATGGAATGTTGTGGAGATGACCCCTCCCTGTGCCGGCTGGTTCCTCTCCCTT TTCCCCTGGTCACGGCTACTCATGGAAGCAGGACCAGTAAGGGACCTTCGATTAAAAAAA AAAAAGACAATAATAAAAAAAAAAAAAAAAAACTCGAC >OriGene 5' read for NM_005507 unedited
NGGTTCACATTTGTATACGACTCACTATAGGCGGCCGCGATTCGGCACGAGGCTGCAGCG CTCTCGTCTTCTGCGGCTCTCGGTGCCCTCTCCTTTTCGTTTCCGGAAACATGGCCTCCG GTGTGGCTGTCTCTGATGGTGTCATCAAGGTGTTCAACGACATGAAGGTGCGTAAGTCTT CAACGCCAGAGGAGGTGAAGAAGCGCAAGAAGGCGGTGCTCTTCTGCCTGAGTGAGGACA AGAAGAACATCATCCTGGAGGAGGGCAAGGAGATCCTGGTGGGCGATGTGGGCCAGACTG TCGACGATCCCTACGCCACCTTTGTCAAGATGCTGCCAGATAAGGACTGCCGCTATGCCC TCTATGATGCAACCTATGAGACCAAGGAGAGCAAGAAGGAGGATCTGGTGTTTATCTTCT GGGCCCCCGAGTCTGCGCCCCTTAAGAGCAAAATGATTTATGCCAGCTCCAAGGACGCCA TCAAGAAGAAGCTGACAGGGATCAAGCATGAATTGCAAGCAAACTGCTACGAGGAGGTCA AGGACCGCTGCACCCTGGCAGAGAAGCTGGGGGGCAGTGCCGTCATCTCCCTGGAGGGCA AGCCTTTGTGAGCCCCTTCTGGCCCCCTGCCTGGAGCATCTGGCAGCCCCACACCTGCCC TTGGGGGTTGCAGGCTGCCCCCTTCCTGCCAGACCGGAGGGGCTGGGGGGATCCCAGCAG GGGGAGGGCAATCCCTTCACCCCAGTTGCCAAACAGACCCCCCCACCCCTGGATTNTCCT TCTCCCTTCATNNCCTTGACGTTCTGGCCTTTCCAAACTGCNTTTGATCTTTTGATTCCT CTTGNNGCTGAGCAGACCAAGTTCCCCCCCAGCACCCCANTGTGGGGGAGCCTGTATTTT TTTAACACA >OriGene 3' read for NM_005507 unedited
GCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTATTATTGGCTTTTTTTTTTT TAATCGAAGGTCCCTTACTGGTCCTGCTTCCATGAGTAGCCGTGACCAGGGGAAAAGGGA GAGGAACCAGCCGGCACAGGGAGGGGTCATCTCCACAACATTCCATTTATACACAGAACT AAACAGACAAGCACAGAGTCACTATTGCGGTTAAAAGTTGGCAGCATGGGAAGGGGGAGG ACCAGGTGGGGAATGGGGATGTTGTTAAAAAAAATACAGGCTCCCCCACAACTGGGGTGC CTGGGGGGAACTTGGTCTGCTTCAGCCCAAGAGGAATCAAAAGATCAAAAGCAGTTTGGG AAGGCCAGAACCGTCAAGGGATGGAGGGAGAAGGAAAATCCAGGGGGTGGGGGGTCTGTT TGGCAACTGGGGTGAAGGGATTGCCCTCCCCCTGCTGGGATCCCCCCAGCCCCTCCGGTC TGGCAGGAAGGGGGCAGCCTGCAACCCCCAAGGGCAGGTGTGGGGCTGCCAGATGCTCCA GGCAGGGGGCCAGAAGGGGCTCACAAAGGCTTGCCCTCCAGGGAGATGACGGCACTGCCC CCCAGCTTCTCTGCCAGGGTGCAGCGGTCCTTGACCTCCTCGTAGCAGTTTGCTTGCAAT TCATGCTTGATCCCTGTCAGCTTCTTCTTGATGGCGTCCTTGGAGCTGGCATAAATCATT TTGCTCTTAAGGGGCGCAGACTCGGGGGCCCCAGAAGAAAACACCAGATCCTNCTTCTTG CTCTNCTGGNCTCATANGTTGCATCATAAAGGGCATAGCGGCAGTCCCTATCTGGCAGCA TCTTGACAAAGTGGGCGTAAGGAACGTNAAACGTCTGGGCCAAATGGGCAACCAGGACTC CTTGCCCTCTCCAGAAAGAGGTCTTCTTTGCCTACTCAGGCAAAGAGACCCGCTTCTGCC CTCTCACCCCTTTGGGAG |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005507 |
| Insert Size | 1200 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_005507.2, NP_005498.1 |
| RefSeq Size | 1260 bp |
| RefSeq ORF | 501 bp |
| Locus ID | 1072 |
| UniProt ID | P23528 |
| Domains | ADF |
| Protein Families | Druggable Genome |
| Protein Pathways | Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton |
| Gene Summary | The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004] |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
The interactions between SATB1 and F-actin are important for mechanisms of active cell death
,Grzanka, D;Kowalczyk, AE;,
Folia Histochemica et Cytobiologica
[CFL1]
|
|
Taurine Chloramine-Induced Inactivation of Cofilin Protein through Methionine Oxidation
,Luo, S;Uehara, H;Shacter, E;,
Free Radic. Biol. Med. July 2014
,PubMed ID 25058340
[CFL1]
|
|
Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin
,Fábio Klamt, Stéphanie Zdanov, Rodney L. Levine, Ashley Pariser, Yaqin Zhang, Baolin Zhang, Li-Rong Yu, Timothy D. Veenstra, Emily Shacter,
Nature Cell Biology 11, 1241-1246 (6 September 2009) doi:10.1038/ncb1968 Letter
[CFL1]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC203585 | CFL1 (Myc-DDK-tagged)-Human cofilin 1 (non-muscle) (CFL1) |
CNY 1200.00 |
|
| RC203585L1 | Lenti ORF clone of Human cofilin 1 (non-muscle) (CFL1), Myc-DDK-tagged |
CNY 3600.00 |
|
| RC203585L2 | Lenti ORF clone of Human cofilin 1 (non-muscle) (CFL1), mGFP tagged |
CNY 5890.00 |
|
| RC203585L3 | Lenti ORF clone of Human cofilin 1 (non-muscle) (CFL1), Myc-DDK-tagged |
CNY 3600.00 |
|
| RC203585L4 | Lenti ORF clone of Human cofilin 1 (non-muscle) (CFL1), mGFP tagged |
CNY 3600.00 |
|
| RG203585 | CFL1 (tGFP-tagged) - Human cofilin 1 (non-muscle) (CFL1) |
CNY 2800.00 |
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