MTH1 (NUDT1) (NM_002452) Human Untagged Clone
CAT＃: SC118636
NUDT1 (untagged)-Human nudix (nucleoside diphosphate linked moiety X)-type motif 1 (NUDT1), transcript variant 1
CNY 1200.00
CNY 3990.00
| Cited in 1 publication. |
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热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | MTH1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_002452, the custom clone sequence may differ by one or more nucleotides
ATGGGCGCCTCCAGGCTCTATACCCTGGTGCTGGTCCTGCAGCCTCAGCGAGTTCTCCTGGGCATGAAAA AGCGAGGCTTCGGGGCCGGCCGGTGGAATGGCTTTGGGGGCAAAGTGCAAGAAGGAGAGACCATCGAGGA TGGGGCTAGGAGGGAGCTGCAGGAGGAGAGCGGTCTGACAGTGGACGCCCTGCACAAGGTGGGCCAGATC GTGTTTGAGTTCGTGGGCGAGCCTGAGCTCATGGACGTGCATGTCTTCTGCACAGACAGCATCCAGGGGA CCCCCGTGGAGAGCGACGAAATGCGCCCATGCTGGTTCCAGCTGGATCAGATCCCCTTCAAGGACATGTG GCCCGACGACAGCTACTGGTTTCCACTCCTGCTTCAGAAGAAGAAATTCCACGGGTACTTCAAGTTCCAG GGTCAGGACACCATCCTGGACTACACACTCCGCGAGGTGGACACGGTCTAG >OriGene 5' read for NM_002452 unedited
AATTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACGAGGGTGGTGACCAGG TTTCTTGCCTTGATGTACTGGAGCAATCAGAAACACGGCGGCTTGGAGAAACCCAGGGAC CATGGGCGCCTCCAGGCTCTATACCCTGGTGCTGGTCCTGCAGCCTCAGCGAGTTCTCCT GGGCATGAAAAAGCGAGGCTTCGGGGCCGGCCGGTGGAATGGCTTTGGGGGCAAAGTGCA AGAAGGAGAGACCATCGAGGATGGGGCTAGGAGGGAGCTGCAGGAGGAGAGCGGTCTGAC AGTGGACGCCCTGCACAAGGTGGGCCAGATCGTGTTTGAGTTCGTGGGCGAGCCTGAGCT CATGGACGTGCATGTCTTCTGCACAGACAGCATCCAGGGGACCCCCGTGGAGAGCGACGA AATGCGCCCATGCTGGTTNCAGCTGGATCAGATCCCCTTCAAGGACATGTGGCCCGACGA CAGCTACTGGTTTCCACTCCTGCTTCAGAAGAAGAAATTCCACGGGTACTTCAAGTTCCA GGGTCAGGACACCATCCTGGACTACACACTCCGCGAGGTGGACACGGTCTAGCGGGAGCC CAGGCAGCCCCTGGGCAGGAGACGTGGCTGCTGAACAGTCGCAAACCATCTTNACCTGGG GGCATTGAGTGGCGCACACGCCGGCTTTCATCTGGAATTAACCTGCATGGAAAGCCAAAT AAAGCCATCTAGCGGGGGGAAAAAAAAAAATAAAACTCGACTCTACATTGCCGCCGCGGC CATAGCTGTTTCCTGAACAAATCCCGGTTGGCATCCCTGGGACCCCCTCCCAGTGCCTCT TCCTGGCCCTGGAAGTTGCCACTCCAGGGCCCCCCAACCTTGTNCTAAAAAACAAGCTGC CTATTGTGC >OriGene 3' read for NM_002452 unedited
CGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTACACCGCTAGCAAGCTTTATTT TGCCTTCCTCCAGTTAATTCCAGATGAAACCCGGCTCTGCGCCACTCAATGCCCCCAGCT GAAGATGGTTTGTGGATGTCCAAAAGCCACGTCTCCTGCCCAGGGGCTGCACTGGGCTAC CGCTACACCGTGTACACCTCGCGGAGTGTGCACACCAGGATGGTGTCCTGACCCTGGAAC TTGAAGTACCCGCGGAATTTCTTATTCTGAAGCAGGAGTGGAAACCACTATCTGCCGCAG GCCCACATGTACTTGAAGGGGATCTGATCCACCTGGAACCAGCATGGGCGCATTCCCCCG CTCTACACGGGGGCCCCCCTGAATGCTGCCTGTGCACAAGACATGCACGTCCATGAGCTC AGGCTCGTCCACGAACTGAAACACGATCTGGCCCACCTTGTGCAGGGCGAACACTGCCAA ACCGATCTACTACTGGAGCTGACTGCTAGGCGCATGCTGCATGGCCCTTACTTATTGCAC TTTGCACCCAAAGCCCATTCTACCGGCCGGCCCCGAAGACTCACTTTTTCATGCCCAGCA CAACTCGCTGAGGCTGCAGGACCACTACCAGGGCATACAGCCTGCAGGCCCACATGGAAC CTGGGTTCCTCCAGCCGACGCGGGATCTGATTGCTCCAGTACATCAAGGCAAGAAACCTG GCCCTACCCTCGTGCCGAATTATGGCCGTCCTATGTGAGCGCCTTACAAATTGTGACGAC TACTAACGAGCTTGCTTATATAACCTGAACCGTCACGCTAACGACATGGCGCCACGGGGC GGGGTATACCACTTTGGAAGCTCGCGATTTGGGCCAAACAACTCCTTGCGTAATGGGGGA GATTGCAATACGGAGCAACGGTTTCGCCATGTGTCCTCAACCCCATCCTGT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_002452 |
| Insert Size | 800 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_002452.3, NP_002443.3 |
| RefSeq Size | 692 bp |
| RefSeq ORF | 471 bp |
| Locus ID | 4521 |
| UniProt ID | P36639 |
| Domains | NUDIX |
| Protein Families | Stem cell - Pluripotency |
| Gene Summary | Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018] Transcript Variant: This variant (1) encodes the predominant isoform (p18, also known as MTH1d). Variants 1, 2A, 3A, 4A, and 5 encode the same isoform. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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MTH1 favors mesothelioma progression and mediates paracrine rescue of bystander endothelium from oxidative damage
,null,
JCI Insight
,PubMed ID 32554927
[NUDT1]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208551 | NUDT1 (Myc-DDK-tagged)-Human nudix (nucleoside diphosphate linked moiety X)-type motif 1 (NUDT1), transcript variant 1 |
CNY 1200.00 |
|
| RC208551L3 | Lenti-ORF clone of NUDT1 (Myc-DDK-tagged)-Human nudix (nucleoside diphosphate linked moiety X)-type motif 1 (NUDT1), transcript variant 1 |
CNY 5890.00 |
|
| RC208551L4 | Lenti-ORF clone of NUDT1 (mGFP-tagged)-Human nudix (nucleoside diphosphate linked moiety X)-type motif 1 (NUDT1), transcript variant 1 |
CNY 3600.00 |
|
| RG208551 | NUDT1 (tGFP-tagged) - Human nudix (nucleoside diphosphate linked moiety X)-type motif 1 (NUDT1), transcript variant 1 |
CNY 4370.00 |
