Haptoglobin (HP) (BC058031) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	binding peptide; BP; haptoglobin; haptoglobin, alpha polypeptide; haptoglobin, beta polypeptide; haptoglobin alpha(1S)-beta; haptoglobin alpha(2FS)-beta; HP2-ALPHA-2; HPA1S; MGC111141
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC058031 edited GGGGGCTCTTCCAGAGGCAAGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCT CCTGCTCTGGGGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCTAC CAGTGTAAGAACTACTACAAACTGCGCACAGAAGGAGATGGAGTGTACACCTTAAACAAT GGGAAGCAGTGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGT GGGAAGCCCAAGAATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCC AAAGGCAGCTTTCCCTGGCAGGCTAAGATGGTTTCCCACCATAATCTCACCACAGGTGCC ACGCTGATCAATGAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCA GAAAATGCAACAGCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAG CTTGTAGAGATTGAGAAGGTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGCTC ATCAAACTCAAACAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCA AAGGATTATGCAGAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAAT TTTAAATTTACTGACCATCTGAAGTATGTCATGCTGCCTGTGGCTGACCAAGACCAATGC ATAAGGCATTATGAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGG GTGCAGCCCATACTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGAC ACCTGCTATGGCGATGCGGGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGGACACCTGG TATGCGACTGGGATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTAT GTGAAGGTGACTTCCATCCAGGACTGGGTTCAGAAGACCATAGCTGAGAACTAATGCAAG GCTGGCCGGAAGCCCTTGCCTGAAAGCAAGATTTCAGCCTGGAAGAGGGCAAAGTGGACG GGAGTGGACAGGAGTGGATGCGATAAGATGTGGTTTGAAGCTGATGGGTGCCAGCCCTGC ATTGCTGAGTCAATCAATAAAGAGCTTTCTTTTGACACAAAAAAAAAAAAAAAAAAAAAA AAAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC058031 unedited CGCAGTTCAGGATTTGTAAACCACTTACTATAGGCGGCCCGAATCGCCTTACGCCGGGCT CTTCGAGCAANACGGGCGGAGAGGGGCCTGGGAGCTGTCATTGCCCTCCTGCTCTGGGGA CAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCTACCAGTGTAAGAACT ACTACAAACTGCGCACAGAAGGAGATGGAGTGTACACCTTAAACAATGGGAAGGGGTGGA TAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGA ATCCGGCAAACCCAGTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTC CCTGGCAGGCTAAGATGGTTTCCCACCATAATCTCACCACAGGTGCCACGCTGATCAATG AACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAG CGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTG AGAAGGTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGGTCATCAAACTCAAAC AGAAAGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCCTTCAAGGGTTATGCAA AATAAGGGCGTGTGGGTTATGGTTTCTGGCTGGGGGGCGAAATGCCAATTTTAAATTTAC TGACCATCTGAAGTATGTCATGCTGCCTGGGGGCGACCAAACCAATGCTAAAGGGATATG GAAAGGCGGCAAATCCCCCCAAAAAAGAACACCAANAGCCCTGGGGGGGGCAGCCCATAC TGATGGACCCCCTTCTGTGCGGGCGGTTTAAGACCAAAAAACCCCGGCTGGGGATCG
Restriction Sites	Please inquire
ACCN	BC058031
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC058031.1, AAH58031.1
RefSeq Size	1207 bp
RefSeq ORF	684 bp
Locus ID	3240
Protein Families	Druggable Genome, Protease, Secreted Protein, Transmembrane
Gene Summary	This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

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