MAX (BC004516) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; helix-loop-helix zipper protein; MAX protein; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; myc-associated factor X; MYC associated factor X; orf1
Vector	pCMV6-XL5
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >OriGene sequence for BC004516 edited GAGAGAGTGAGTGAGTGAGTGAGTGTGTGTGTGGGGGGGACTCGGCTTGTTGTTGTCGGT GACTTCCCCCTCCCCTTCACCCCTTCCCCTCCCCGCCGCCGCTGCAGTGGCCGCTCCCTG GGCCGTAGGAAATGAGCGATAACGATGACATCGAGGTGGAGAGCGACGAAGAGCAACCGA GGTTTCAATCTGCGGCTGACAAACGGGCTCATCATAATGCACTGGAACGAAAACGTAGGG ACCACATCAAAGACAGCTTTCACAGTTTGCGGGACTCAGTCCCATCACTCCAAGGAGAGA AGGCATCCCGGGCCCAAATCCTAGACAAAGCCACAGAATATATCCAGTATATGCGAAGGA AAAACCACACACACCAGCAAGATATTGACGACCTCAAGCGGCAGAATGCTCTTCTGGAGC AGCAAGTCCGTGCACTGGAGAAGGCGAGGTCAAGTGCCCAACTGCAGACCAACTACCCCT CCTCAGACAACAGCCTCTACACCAACGCCAAGGGCAGCACCATCTCTGCCTTCGATGGGG GCTCGGACTCCAGCTCGGAGTCTGAGCCTGAAGAGCCCCAAAGCAGGAAGAAGCTCCGGA TGGAGGCCAGCTAAGCCACTCGGGGCAGGCCAGCAATAAAAACTGTCTGTCTCCATCGTC TCATCCTCCTTTCAGTTCGTTGGTAGAGCCCTCAGAACCATTTAAAAGACTCTTTATTTT TCTCTTTCTCCCTTTTTTTTTTAAATTTTTATTTTTACGTAGAAGCTCTTGGACAACAGC TCTCGTTCTCCTTCCCCATTTCCACTGTATATTTTTTAATGTATTCCCTTCAGGGATTCC CTGTCCCCAACAGGAATTTTTAAACCAAAACACCCCAACTTGGCAGCTTTTTCTGTGGAG GACAGACGGCCGGCCGGACCTCTGAGCACATAGTGTCCTGCCCACCCTACCAGCTCCTCC AGCCCTGCCGGGCACATGCCCGGGGGACGCCTGCCCTGCCCAGGTGGCCTCCTGGCCTGC CCTCACCTCTGATAGACTTTGTGAATCTGAACTGCTCTACTTTGAGAAGATGACCGGTTT GGAGTAATCAGAATGAACCCTCCTCCTTTTTAAGGGTTTTTTTTTTTTCCTTTTTCTAAA AAGCTATGTATCGCTCCTATTGAAAGACCAGATCCTTAAAGAAGTTTGTGGTATAAAAAG AAAGTGGGGACAGATTCGCAGCACAGAGTCGCTGGCATGTTTCACTCCTGCTTCTCTCAG CCAGCTGTTTAAGCCTGCGGCGCCAGCCTCACGGAGGGCCGTGTGACACTCTCGTGGTAT GTATGGGAGACGGCAGCAGTGAAGCAGCAGCCACCAGGGAGTGGCCATTTGGGGTTGGGA CAGGGAGGGTGTTTTGGGTGGCATAGAGGTTTTGTATTGAGGGCCAGTGATGATGTTTTG ATATTTATTTCCTGCTACTTAAATTTGAATCTGAGTGAATTGTACCTATTTCTGATGATG TCGGTCTTGCAAAGCGACAGATTCATAAAGTAATGATGAAATCTTTAAAAAAAAAAAAAA AAAAAA 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for BC004516 unedited TTTTCNCGGGGAAGTTCAGGATTTGTNATACGACTCACTATAGGGCGGACCGCGAATTCG CACGAGGGAGAGAGTGAGTGAGTGAGTGAGTGTGTGTGTGGGGGGGACTCGGCTTGTTGT TGTCGGTGACTTCCCCCTCCCCTTCACCCCTTCCCCTCCCCGCCGCCGCTGCAGTGGCCG CTCCCTGGGCCGTAGGAAATGAGCGATAACGATGACATCGAGGTGGAGAGCGACGAAGAG CAACCGAGGTTTCAATCTGCGGCTGACAAACGGGCTCATCATAATGCACTGGAACGAAAA CGTAGGGACCACATCAAAGACAGCTTTCACAGTTTGCGGGACTCAGTCCCATCACTCCAA GGAGAGAAGGCATCCCGGGCCCAAATCCTAGACCAAGCCACAGAATATATCCAGTATATG CGAAAGGAAAACCACCACACCAGCAGATATTGACGACCTCAGCGGCAGAATGCTCTTTCT GGACACCAAGTCCCTGCCCTGGAAAAAGCAAGGGCAAGGCCCCAACTGGAACCCAATACC CTTCCTTAAAAAAAGCCTTTTACCACCCCAAGGGGAGCCCCCTTTTGCCCTCAAGGGGGG CCCCCACCCCCCCCCGGGGTTTTGACCCCCAAAACCCCCCACCGGGGAAAAAACCCCGGG GAGGGGGCCCCTAATCCCCCCTGGGGGGGGGCCCCAAAAAAAAAAAGGGGGGGCCCCCCT CGTACCTCCCTTTTTTTTGTGGGGGGGGGCCCCCCCCCCCACCAATTAAAAAAACTTTTT TTTTTTTCCCCCCCCCCCCCTCCTTTAAAAAAATTATTTTTNNGAAGAAAAAGTTTGGGG AGGGCAANGTTTTTGTTCCCCCCCCCCCCCTCCGCTTTTTTTTTTTTATTTTGCCCCCG
Restriction Sites	Please inquire
ACCN	BC004516
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	BC004516.2, AAH04516.1
RefSeq Size	1566 bp
Locus ID	4149
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	MAPK signaling pathway, Pathways in cancer, Small cell lung cancer
Gene Summary	The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

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