MLSTD2 (FAR1) (AK090880) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	MLSTD2; PFCRD; SDR10E1
Vector	pCMV6-XL4
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	None
Sequence Data	Fully Sequenced ORF (showhide) >NCBI ORF sequence for AK090880, the custom clone sequence may differ by one or more nucleotides TTGTTGTATCTTTTTGTTTAGAAAAAAATAATCACCTAATCTTTTCTAAGAGCAGCATGTGTTTTTCCCC CAGATGCTTTTTATCTACAGAACTATCCCTGTCCAGAAATTGCCTTAGATGCTTGATAATTCGTTTTGTG TTTGAGATTTTATTTTGAAGTTACTTTATTGGATGAAATATAGTTCTTTTTTACATAGTTTACATTGCTT CATTTTCTTCCAGTATTCTGGATTCAGAGTTTATTTCTAAATGTATTGAATTGTGTTATCAGAAGTGCTT AGCTAATGATACTTTTTTGATTTTTTTCTCCTTATTTCTAATGTAATTTCCCTCCATGCCCCTCCCATTT CTAAAACCCCTAATTTTGAGACTGTCTAAACTACATGATACATATAATCCTAATCTTTATTATAATATAA ATGAAATCTTTAAAAAGTACTTCTCCAAAAATTCTTTTTCTGTTCACAGAAGTGGGGATTTTTTTGGTGT TTGCTTTGTTTCAGAAAGTTCTTTCTTCCCTTTCCCTACTTATAATAAATATTATTGTATAGATGTTACT GCTCAAGTTAGTGTTATGATATCAATGACTTACAGTGAGCCATGATATATAAAATGACAGATTTAAAGAT TAAAGCTCCTTGTACTTTTAAAAACAAAGAATCACAGTCTTTCTTTAAAGACACACTTTAAAAAGAGTGT CACACTCCTTTATTTCTGTAAGGATGAGTATTGGTGGGGTATGGAGAGGTGAGTGGATATCTATTTCAGA TAGTTTTCAGCATGAGTCATTGATTTCACAGCACATCCAGATGATCAAGAGTGGTGCCAATCATTGTTAA AGAAAAGTTGTTTTGTTTTTTTAAATGAATAGAGTTGACTATGTGGCAAACGAATATTTCTGTATTCTTT GCTTCAGCAGTGCTGAAGAGTTGGAATTATAAATATAACACAGTATGTTATTAATTCACAGGAAATCTTA GCAAATGCAGCTGTGAATTAAAATGTAGTTTAAGGAATAGAAAGCAAGGAAATATTAATTGAATCCATTC ATTTGCTTAGTATTTTATGTAGAAAATTTAAGAGTATTGTATACCCTTTGAGAATTAATTCTGTATATCA GCAGAACTCTGTTTAGGTGGTATTAAATGCATTTGCTGCTGCTTTCAAAAAAAATTTGTTTTCCTTTTGG ATTTATAAATTGTTCATCCAAGATGCAGAAATAGTCTTATTCCCTGCTGATTTGGTACACTTAATGATTA AATGTTATAATTTTAATACTAATGTCTATATTATAGGGGGAAACTTGCACCCTGGGTGGTGATAGGATTT TTCCTAATCTATACAAAATATGAATCTGTCCATTTTTCTTACAATACAGGATGATGAAAACAATAACTCG TCTTCACAAAGCTATGGTGTTTCTTGAATATTTCACAAGTAATTCTTGGGTTTGGAATACTGAGAATGTC AATATGTTAATGAATCAACTAAACCCTGAAGATAAAAAGACCTTCAATATTGATGTACGGCAGTTACATT GGGCAGAATATATAGAGAACTACTGCTTGGGAACTAAGAAGTACGTATTGAATGAAGAAATGTCTGGCCT CCCTGCAGCCAGAAAACATCTGAACAAGTTGCGGAATATACGTTATGGTTTTAATACTATCCTTGTGATC CTCATCTGGCGCATTTTTATTGCAAGATCACAAATGGCAAGAAATATCTGGTACTTTGTGGTTAGTCTGT GTTACAAGTTTTTGTCATACTTCCGAGCATCCAGCACTATGAGATACTGAAGACCAAGGATTCAGCATTA GAACATCTATACATATGGTGATCTAAATGTACAAAATGTAAAATGTATAAGTCATCTCACTTTTTGTCAA GACATTAAACCATCTTAGATCGGAGTGTGAAGTAAATTATGGTATATTTTATGTAACATTTTAATGTTTA TGCTCATAAAACTTAGTGAACACACTGTGTTATGCCAGCTCAAATCTACAGTAGCCACCAAAACCATGAC TTAATATTTTGAGCCCTAGAAGAAAGGGGTGTGCTGAGGACAAGAGTGGGGAAATAGGAACACTGACCAG TATAACTGTGCAATTCTGGAACATATTAATTAAAATAATATGCCTTAACATATAGTGAATTTCTAATTCT AATGTTCAGTGCAATGGAAGACATTTATTTGGACAGTAATACTAGCAAAGTTGGTAGATATTTGATTCTT CATTTTTTGTTTTTTTCATTAGTTGAAGTGGGTTTTAGTTTTGTTTAAAATTATAACCAGCGTATTTTCA CATCATTCTGTAAGTTAAATGATATCAAACATGAAAGAGATGTTATTTTTCTTTTTCTGATTAAACGTCT GATGCATATCATTTTTCTATAAGTAATCAGTTGCTTTTAAAATCAGAAGGCTATATTATTCTAATGACCC TATTCGATCTAAATGGGTTTGAGAATCCATATCAGCAACATACGTGTTTTTTTGACAGAAAGTGAAAACA AATTCCGTAAAACTGTTAGTATCAAAAAGAATAGGAATACAGTTTTCTTTTCCACATTATGATCAAATAA AAATCTTGTGAGATTGTTTATGTTTTGAAGCAGGAGGATTTCTTGAGATTTGATGGAAGTGGGAGTTGGG AAGGATTCACCATACTTGTGTTCTCCTCCCTTTATAAATTTTATTCATAGGACTTTTAAAAGGCTTGTGC TATCTTTCCAGTGAAAACTGAAAGTGCATTATTATGGAAGAATGTATTTGCAGGTAGTAATAGCATTAAA AAATATACTCGTGTGTAAACACATACTAATTTTGACCTTGAAAGATGAATTCCTTCAAGAAAAATAAAAT AATGCTTAAGATAATGTGTACGAAATTAAATAAAGGACTTTATTTACATACTACATAAGGTAGCAAACTG TTGAATGAGTTTGAAGGTATCACTTATTTTTTATGCATGTGGTTTTAGCTTTAGAAAGAAATGCGTTATA GAAACAAGTAATAGCAAGAAAATTGATGTATATTTTAATGATACATTAAAATTCCCTTTTAATCAT 5' Read Nucleotide Sequence (showhide) >OriGene 5' read for AK090880 unedited TGTATACGACTCCTATAGGCGGCCCGCGAATTCGCACGAGGGATTTTTCCTAATCTATAC AAAATATGAATCTGTCCATTTTTCTTACAATACAGGATGATGAAAACAATAACTCGTCTT CACAAAGCTATGGTGTTTCTTGAATATTTCACAAGTAATTCTTGGGTTTGGAATACTGAG AATGTCAATATGTTAATGAATCAACTAAACCCTGAAGATAAAAAGACCTTCAATATTGAT GTACGGCAGTTACATTGGGCAGAATATATAGAGAACTACTGCTTGGGAACTAAGAAGTAC GTATTGAATGAAGAAATGTCTGGCCTCCCTGCAGCCAGAAAACATCTGAACAAGTTGCGG AATATACGTTATGGTTTTAATACTATCCTTGTGATCCTCATCTGGCGCATTTTTATTGCA AGATCACAAATGGCAAGAAATATCTGGTACTTTGTGGTTAGTCTGTGTTACAAGTTTTTG TCATACTTCCGAGCATCCAGCACTATGAGATACTGAAGACCAAGGATTCAGCATTAGAAC ATCTATANCATATGGTGATCTAAATGTACAAAATGTAAAATGTATAAGTCATCTCACTTT TTGTCAAGACATTAAACCATCTTAGATCGGAGTGTGAAGTAAATTATGGTATATTTTATG TAACATTNTAATGTTTATGCTCATAAAACTTAGTGAACACACTGTGTTATGCCAGCTCAN ATCTACAGTAGCCACCAAAACCATGACTTAATATTNTTGAGCCCTAAAGAAAAAGGGGTG TGCTGAGGACCAGAGTGGGGAAATAGGAACCACTGACCAGTATAACTGTGCCATTCTGGA ACAATATAATAAAATAATATGCCTTAACATATAGNGAATTTCTATTTCTAAC
Restriction Sites	NotI-NotI
ACCN	AK090880
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	AK090880.1
RefSeq Size	3076 bp
RefSeq ORF	3076 bp
Locus ID	84188
Protein Families	Transmembrane
Gene Summary	The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]

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