RICH2 (ARHGAP44) (NM_014859) Human Untagged Clone
CAT＃: SC310095
ARHGAP44 (untagged)-Human Rho GTPase activating protein 44 (ARHGAP44)
CNY 7220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | NPC-A-10; RICH2 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_014859, the custom clone sequence may differ by one or more nucleotides
ATGAAGAAGCAGTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAA AAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAAGCGTCTGGAGCTGGTGAAA CAGGTGTCCCACAGCACGCACAAGAAGCTCACCGCATGTCTGCAGGGCCAGCAAGGGGCA GAGGCTGACAAGCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAG GGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGATGCTGAAACTCTGTGGAGAG ACGGAGGACAAGCTGGCTCAGGAGCTGATACATTTTGAGTTGCAAGTAGAGAGAGACGTG ATTGAGCCCCTGTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAA CACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAACCAGGTGGCAGCAGACTTCC AAGTCTTCAGGTTTGTCCAGCAGCTTACAGCCTGCGGGTGCCAAGGCTGATGCCCTCAGG GAAGAAATGGAAGAGGCTGCCAACAGAGTGGAGATTTGCAGGGACCAGCTCTCAGCTGAT ATGTACAGTTTTGTGGCCAAAGAAATTGACTATGCAAACTACTTTCAAACGCTAATAGAA GTGCAAGCTGAATACCACAGGAAGTCCCTGACACTATTGCAGGCTGTATTGCCTCAGATC AAAGCACAACAGGAGGCCTGGGTAGAGAAGCCTTCCTTCGGGAAGCCGCTGGAGGAGCAC CTCACCATCAGCGGCCGGGAGATCGCCTTCCCCATCGAGGCGTGTGTGACCATGCTGCTT GAGTGTGGGATGCAGGAGGAGGGACTCTTCCGAGTAGCCCCCTCTGCCTCCAAACTGAAG AAGCTGAAAGCGGCCCTGGACTGCTGCGTGGTGGATGTGCAGGAGTACTCGGCAGACCCC CACGCAATTGCAGGAGCTTTGAAATCTTACCTCCGAGAGTTGCCAGAACCTCTTATGACC TTTGAACTCTATGATGAGTGGATCCAGGCTTCCAATGTCCAGGAGCAAGACAAGAAGCTT CAGGCTCTATGGAATGCTTGTGAAAAGTTGCCCAAGGCCAATCACAACAACATCCGATAC TTGATAAAATTTTTATCCAAGCTGTCAGAATATCAAGATGTAAACAAGATGACTCCCAGT AATATGGCAATTGTTTTAGGACCCAACCTCCTATGGCCACAAGCAGAAGGGAACATTACA GAGATGATGACCACAGTGTCGCTGCAAATTGTTGGGATCATTGAACCTATCATCCAGCAT GCAGACTGGTTCTTCCCTGGGGAGATAGAGTTCAACATTACTGGCAATTATGGGAGTCCA GTACACGTGAACCATAATGCCAACTACAGCTCAATGCCCTCCCCAGACATGGACCCTGCT GACCGGCGCCAGCCCGAGCAGGCCCGCCGGCCCCTCAGCGTCGCCACGGATAATATGATG CTGGAGTTTTACAAAAAGGATGGCCTTAGGAAAATCCAAAGCATGGGTGTGAGGGTCATG GACACAAACTGGGTGGCTCGAAGAGGCTCCTCGGCCGGTCGGAAAGTGTCCTGCGCCCCG CCCTCCATGCAGCCTCCCGCCCCGCCCGCCGAGCTGGCTGCGCCCCTGCCTTCGCCGCTG CCGGAGCAGCCCCTGGACAGCCCCGCGGCCCCCGCGCTCTCTCCATCCGGCCTGGGCCTC CAGCCTGGGCCCGAGCGCACCAGCACAACAAAAAGCAAGGAACTTTCTCCAGGCTCTGCA CAGAAAGGAAGTCCAGGCTCCAGCCAGGGCACAGCCTGTGCAGGGACTCAACCAGGGGCT CAACCTGGAGCTCAGCCGGGCGCCAGCCCCAGCCCCAGCCAGCCGCCTGCAGACCAGAGT CCTCACACCCTCCGGAAAGTTTCAAAGAAGCTGGCACCGATTCCACCCAAGGTCCCCTTT GGCCAGCCGGGGGCTATGGCAGACCAGTCCGCTGGCCAGCCGTCCCCAGTCAGCCTGTCC CCCACCCCGCCCAGCACCCCGTCACCCTATGGACTGAGCTACCCTCAGGGGTACTCCTTG GCCTCGGGCCAGCTCTCCCCAGCTGCAGCTCCTCCCCTGGCCTCTCCTTCTGTCTTTACA AGCACTTTGAGCAAATCGCGGCCCACTCCTAAGCCGCGACAGAGACCTACTCTGCCGCCT CCTCAGCCTCCCACAGTAAACCTCTCGGCCTCTAGTCCACAGTCCACGGAGGCCCCCATG CTAGATGGCATGTCCCCTGGGGAAAGCATGTCTACAGATCTTGTCCACTTTGATATTCCC TCGATCCACATAGAGCTCGGGTCGACGCTCCGCCTGAGTCCCCTGGAGCACATGCGGCGA CACTCAGTAACTGACAAGAGGGACTCGGAGGAGGAGTCTGAGAGCACCGCCCTCTGA |
| Restriction Sites | Please inquire |
| ACCN | NM_014859 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_014859.3, NP_055674.3 |
| RefSeq Size | 4227 bp |
| RefSeq ORF | 2457 bp |
| Locus ID | 9912 |
| UniProt ID | Q17R89 |
| Domains | RhoGAP, BAR |
| Gene Summary | GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
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| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC213290 | ARHGAP44 (Myc-DDK-tagged)-Human Rho GTPase activating protein 44 (ARHGAP44) |
CNY 5992.00 |
|
| RC213290L3 | Lenti-ORF clone of ARHGAP44 (Myc-DDK-tagged)-Human Rho GTPase activating protein 44 (ARHGAP44) |
CNY 5890.00 |
|
| RC213290L4 | Lenti-ORF clone of ARHGAP44 (mGFP-tagged)-Human Rho GTPase activating protein 44 (ARHGAP44) |
CNY 5890.00 |
|
| RG213290 | ARHGAP44 (tGFP-tagged) - Human Rho GTPase activating protein 44 (ARHGAP44) |
CNY 4370.00 |
