Frizzled 6 (FZD6) (NM_003506) Human Untagged Clone
CAT＃: SC316995
FZD6 (untagged)-Human frizzled family receptor 6 (FZD6), transcript variant 1
CNY 5176.00
CNY 7220.00
| Cited in 3 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | FZ-6; FZ6; HFZ6; NDNC1; NDNC10 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_003506 edited
AGGACTCATTTTCAGGAAAGCCTGAAAATGAGTAAAATAGTGAAATGAGGAATTTGAACA TTTTATCTTTGGATGGGGATCTTCTGAGGATGCAAAGAGTGATTCATCCAAGCCATGTGG TAAAATCAGGAATTTGAAGAAAATGGAGATGTTTACATTTTTGTTGACGTGTATTTTTCT ACCCCTCCTAAGAGGGCACAGTCTCTTCACCTGTGAACCAATTACTGTTCCCAGATGTAT GAAAATGGCCTACAACATGACGTTTTTCCCTAATCTGATGGGTCATTATGACCAGAGTAT TGCCGCGGTGGAAATGGAGCATTTTCTTCCTCTCGCAAATCTGGAATGTTCACCAAACAT TGAAACTTTCCTCTGCAAAGCATTTGTACCAACCTGCATAGAACAAATTCATGTGGTTCC ACCTTGTCGTAAACTTTGTGAGAAAGTATATTCTGATTGCAAAAAATTAATTGACACTTT TGGGATCCGATGGCCTGAGGAGCTTGAATGTGACAGATTACAATACTGTGATGAGACTGT TCCTGTAACTTTTGATCCACACACAGAATTTCTTGGTCCTCAGAAGAAAACAGAACAAGT CCAAAGAGACATTGGATTTTGGTGTCCAAGGCATCTTAAGACTTCTGGGGGACAAGGATA TAAGTTTCTGGGAATTGACCAGTGTGCGCCTCCATGCCCCAACATGTATTTTAAAAGTGA TGAGCTAGAGTTTGCAAAAAGTTTTATTGGAACAGTTTCAATATTTTGTCTTTGTGCAAC TCTGTTCACATTCCTTACTTTTTTAATTGATGTTAGAAGATTCAGATACCCAGAGAGACC AATTATATATTACTCTGTCTGTTACAGCATTGTATCTCTTATGTACTTCATTGGATTTTT GCTGGGCGATAGCACAGCCTGCAATAAGGCAGATGAGAAGCTAGAACTTGGTGACACTGT TGTCCTAGGCTCTCAAAATAAGGCTTGCACCGTTTTGTTCATGCTTTTGTATTTTTTCAC AATGGCTGGCACTGTGTGGTGGGTGATTCTTACCATTACTTGGTTCTTAGCTGCAGGAAG AAAATGGAGTTGTGAAGCCATCGAGCAAAAAGCAGTGTGGTTTCATGCTGTTGCATGGGG AACACCAGGTTTCCTGACTGTTATGCTTCTTGCTCTGAACAAAGTTGAAGGAGACAACAT TAGTGGAGTTTGCTTTGTTGGCCTTTATGACCTGGATGCTTCTCGCTACTTTGTACTCTT GCCACTGTGCCTTTGTGTGTTTGTTGGGCTCTCTCTTCTTTTAGCTGGCATTATTTCCTT AAATCATGTTCGACAAGTCATACAACATGATGGCCGGAACCAAGAAAAACTAAAGAAATT TATGATTCGAATTGGAGTCTTCAGCGGCTTGTATCTTGTGCCATTAGTGACACTTCTCGG ATGTTACGTCTATGAGCAAGTGAACAGGATTACCTGGGAGATAACTTGGGTCTCTGATCA TTGTCGTCAGTACCATATCCCATGTCCTTATCAGGCAAAAGCAAAAGCTCGACCAGAATT GGCTTTATTTATGATAAAATACCTGATGACATTAATTGTTGGCATCTCTGCTGTCTTCTG GGTTGGAAGCAAAAAGACATGCACAGAATGGGCTGGGTTTTTTAAACGAAATCGCAAGAG AGATCCAATCAGTGAAAGTCGAAGAGTACTACAGGAATCATGTGAGTTTTTCTTAAAGCA CAATTCTAAAGTTAAACACAAAAAGAAGCACTATAAACCAAGTTCACACAAGCTGAAGGT CATTTCCAAATCCATGGGAACCAGCACAGGAGCTACAGCAAATCATGGCACTTCTGCAGT AGCAATTACTAGCCATGATTACCTAGGACAAGAAACTTTGACAGAAATCCAAACCTCACC AGAAACATCAATGAGAGAGGTGAAAGCGGACGGAGCTAGCACCCCCAGGTTAAGAGAACA GGACTGTGGTGAACCTGCCTCGCCAGCAGCATCCATCTCCAGACTCTCTGGGGAACAGGT CGACGGGAAGGGCCAGGCAGGCAGTGTATCTGAAAGTGCGCGGAGTGAAGGAAGGATTAG TCCAAAGAGTGATATTACTGACACTGGCCTGGCCCAGAGCAACAATTTGCAGGTCCCCAG TTCTTCAGAACCAAGCAGCCTCAAAGGTTCCACATCTCTGCTTGTTCACCCAGTTTCAGG AGTGAGAAAAGAGCAGGGAGGTGGTTGTCATTCAGATACTTGAAGAACATTTTCTCTCGT TACTCAGAAGCAAATTTGTGTTACACTGGAAGTGACCTATGCACTGTTTTGTAAGAATCA CTGTTACGTTCTTCTTTTGCACTTAAAGTTGCATTGCCTACTGTTATACTGGAAAAAATA GAGTTCAAGAATAATATGACTCATTTCACACAAAGGTTAATGACAACAATATACCTGAAA ACAGAAATGTGCAGGTTAATAATATTTTTTTAATAGTGTGGGAGGACAGAGTTAGAGGAA TCTTCCTTTTCTATTTATGAAGATTCTACTCTTGGTAAGAGTATTTTAAGATGTACTATG CTATTTTACTTTTTTGATATAAAATCAAGATATTTCTTTGCTGAAGTATTTAAATCTTAT CCTTGTATCTTTTTATACATATTTGAAAATAAGCTTATATGTATTTGAACTTTTTTGAAA TCCTATTCAAGTATTTTTATCATGCTATTGTGATATTTTAGCACTTTGGTAGCTTTTACA CTGAATTTCTAAGAAAATTGTAAAATAGTCTTCTTTTATACTGTAAAAAAAGATATACCA AAAAGTCTTATAATAGGAATTTAACTTTAAAAACCCACTTATTGATACCTTACCATCTAA AATGTGTGATTTTTATAGTCTCGTTTTAGGAATTTCACAGATCTAAATTATGTAACTGAA ATAAGGTGCTTACTCAAAGAGTGTCCACTATTGATTGTATTATGCTGCTCACTGATCCTT CTGCATATTTAAAATAAAATGTCCTAAAGGGTTAGTAGACAAAATGTTAGTCTTTTGTAT ATTAGGCCAAGTGCAATTGACTTCCCTTTTTTAATGTTTCATGACCACCCATTGATTGTA TTATAACCACTTACAGTTGCTTATATTTTTTGTTTTAACTTTTGTTTTTTAACATTTAGA ATATTACATTTTGTATTATACAGTACCTTTCTCAGACATTTTGTAGAATTCATTTCGGCA GCTCACTAGGATTTTGCTGAACATTAAAAAGTGTGATAGCGATATTAGTGCCAATCAAAT GGAAAAAAGGTAGTCTTAATAAACAAGACACAACGTTTTTATACAACATACTTTAAAATA TTAAGGAGTTTTCTTAATTTTGTTTCCTATTAAGTATTATTCTTTGGGCAAGATTTTCTG ATGCTTTTGATTTTCTCTCAATTTAGCATTTGCTTTTGGTTTTTTTCTCTATTTAGCATT CTGTTAAGGCACAAAAACTATGTACTGTATGGGAAATGTTGTAAATATTACCTTTTCCAC ATTTTAAACAGACAACTTTGAATACAAAAAAAAAAAAAAAAAA >OriGene 5' read for NM_003506 unedited
GACCGCCCCCCGAGTAATTGACCCAGGACTCATTTTCAGGAAAGCCTGAAAATGAGTAAA ATAGTGAAATGAGGAATTTGAACATTTTATCTTTGGATGGGGATCTTCTGAGGATGCAAA GAGTGATTCATCCAAGCCATGTGGTAAAATCAGGAATTTGAAGAAAATGGAGATGTTTAC ATTTTTGTTGACGTGTATTTTTCTACCCCTCCTAAGAGGGCACAGTCTCTTCACCTGTGA ACCAATTACTGTTCCCAGATGTATGAAAATGGCCTACAACATGACGTTTTTCCCTAATCT GATGGGTCATTATGACCAGAGTATTGCCGCGGTGGAAATGGAGCATTTTCTTCCTCTCGC AAATCTGGAATGTTCACCAAACATTGAAACTTTCCTCTGCAAGCATTTGTACCAACCTGC ATAGAACAAATTCATGTGGTTCCACCTTGTCGTAAACTTTGTGAGAAAGTATATTCTGAT TGCAAAAAATTAATTGACACTTTTGGGATCCCGATGGCCTGAGGAGCTTGAATGTGACAG ATTACAATACTGTGATGAGACTGTTCCTGGTACTTTTTGATCCACACACAGAATTTCTTG GGTTCTCAGAAGAAACAGAACAAGTCCAAAGAAAATTTGGATTTTTGGTGCCCAAGGATC TTAAGACTTCTGGGGGACAGGGTATATATGTTCTTGGGATTGACCAGTGGGCGCCTCCTT GCCCTACTTGTTTTTAAAAGTGATGAACTTAGTTGGCAAAGATTTATTGGACAATTCAAT ATTTGTGCTTTGGCAACTTTGTCCATTCTTCTTTTTTATGAGGTATAAAATCCATACC >OriGene 3' read for NM_003506 unedited
GGGGTACGTGNACCGCGGCCCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGTATTCA AAGTTGTCTGTTTAAAATGTGGAAAAGGTAATATTTACAACATTTCCCATACAGTACATA GTTTTTGTGCCTTAACAGAATGCTAAATAGAGAAAAAAACCAAAAGCAAATGCTAAATTG AGAGAAAATCAAAAGCATCAGAAAATCTTGCCCAAAGAATAATACTTAATAGGAAACAAA ATTAAGAAAACTCCTCAATATTTTAAAGTATGTTGTATAAAAACGTTGTGTCTTGTTTAT TAAGACTACCTTTTTTCCATTTGATTGGCACTAATATCGCTATCACACTTTTTAATGTTC AGCAAAATCCTAGTGAGCTGCCGAAATGAATTCTACAAAATGTCTGAGAAAGGTACTGTA TAATACAAAATGTAATATTCTAAATGTTAAAAAATCAAAAGTTAAAACAAAAAATATAAG CAACTGTAAGTGGTTATAATACAATCAATGGGTGGTCATGAAACATTAAAAAAGGGAAGT CAATTGCACTTGGCCTAATATACAAAAGACTAACATTTTGTCTACTAACCCTTTAGGACA TTTTATTTTAAATATGCAGAAGGATCAGTGAGCAGCATAATACAATCAATAGTGGACACT CTTTGAGTAAGCACCTTATTTCAGTTACATAATTTAGATCTGTGAAATTCCTAANACGAG ACTATAAAAATCACACATTNTAGATGGTAAGGTATCAATAAGTGGGTTTTTAAAGTTAAA TTCCTATTATAAGACTTTTTTGGTATATCTTTNTTTACAGTATAAAAGAAGACTATTTTA CAAATTTCTTAGAATTCAGTGTAAAAGCTACCAAAGTGCTAAAATATCACAATAGCATGA TAAAAAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_003506 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.NA |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_003506.2, NP_003497.2 |
| RefSeq Size | 3768 bp |
| RefSeq ORF | 2121 bp |
| Locus ID | 8323 |
| UniProt ID | O60353 |
| Domains | FRI, Frizzled |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway |
| Gene Summary | This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011] Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (3)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families
,null,
The FASEB Journal
,PubMed ID 28733458
[FZD6]
|
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Secreted Frizzled-related protein-1 is a negative regulator of androgen receptor activity in prostate cancer
,Y Kawano, S Diez, P Uysal-Onganer, R S Darrington, J Waxman, R M Kypta,
British Journal of Cancer 100, 1165-1174 (10 March 2009)
[FZD6]
|
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R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
,ME Binnerts, KA Kim, JM Bright, SM Patel, K Tran, M Zhou, JM Leung, Y Liu, WE Lomas 3rd, M Dixon, SA Hazell, M Wagle, WS Nie, N Tomasevic, J Williams, X Zhan, MD Levy, WD Funk, and A Abo,
Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14700-5.
[FZD6]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209270 | FZD6 (Myc-DDK-tagged)-Human frizzled family receptor 6 (FZD6), transcript variant 1 |
CNY 5168.00 |
|
| RC209270L1 | Lenti ORF clone of Human frizzled family receptor 6 (FZD6), transcript variant 1, Myc-DDK-tagged |
CNY 7568.00 |
|
| RC209270L2 | Lenti ORF clone of Human frizzled family receptor 6 (FZD6), transcript variant 1, mGFP tagged |
CNY 5890.00 |
|
| RC209270L3 | Lenti ORF clone of Human frizzled family receptor 6 (FZD6), transcript variant 1, Myc-DDK-tagged |
CNY 5890.00 |
|
| RC209270L4 | Lenti ORF clone of Human frizzled family receptor 6 (FZD6), transcript variant 1, mGFP tagged |
CNY 5890.00 |
|
| RG209270 | FZD6 (tGFP-tagged) - Human frizzled family receptor 6 (FZD6), transcript variant 1 |
CNY 6768.00 |
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