IL18R1 (NM_001282399) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	CD218a; CDw218a; IL-1Rrp; IL-18R-alpha; IL-18Ralpha; IL1RRP; IL18RA; IL18Ralpha2
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >SC335784 representing NM_001282399. Blue=Insert sequence Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGAACTGTAAAAAGCTACTACTGGAGAACAATAAAAACCCAACGATAAAGAAGAACGCCGAGTTTGAA GATCAGGGGTATTACTCCTGCGTGCATTTCCTTCATCATAATGGAAAACTATTTAATATCACCAAAACC TTCAATATAACAATAGTGGAAGATCGCAGTAATATAGTTCCGGTTCTTCTTGGACCAAAGCTTAACCAT GTTGCAGTGGAATTAGGAAAAAACGTAAGGCTCAACTGCTCTGCTTTGCTGAATGAAGAGGATGTAATT TATTGGATGTTCGGGGAAGAAAATGGATCGGATCCTAATATACATGAAGAGAAAGAAATGAGAATTATG ACTCCAGAAGGCAAATGGCATGCTTCAAAAGTATTGAGAATTGAAAATATTGGTGAAAGCAATCTAAAT GTTTTATATAATTGCACTGTGGCCAGCACGGGAGGCACAGACACCAAAAGCTTCATCTTGGTGAGAAAA GACATGGCTGATATCCCAGGCCACGTCTTCACAAGAGGAATGATCATAGCTGTTTTGATCTTGGTGGCA GTAGTGTGCCTAGTGACTGTGTGTGTCATTTATAGAGTTGACTTGGTTCTATTTTATAGACATTTAACG AGAAGAGATGAAACATTAACAGATGGAAAAACATATGATGCTTTTGTGTCTTACCTAAAAGAATGCCGA CCTGAAAATGGAGAGGAGCACACCTTTGCTGTGGAGATTTTGCCCAGGGTGTTGGAGAAACATTTTGGG TATAAGTTATGCATATTTGAAAGGGATGTAGTGCCTGGAGGAGCTGTTGTTGATGAAATCCACTCACTG ATAGAGAAAAGCCGAAGACTAATCATTGTCCTAAGTAAAAGTTATATGTCTAATGAGGTCAGGTATGAA CTTGAAAGTGGACTCCATGAAGCATTGGTGGAAAGAAAAATTAAAATAATCTTAATTGAATTTACACCT GTTACTGACTTCACATTCTTGCCCCAATCACTAAAGCTTTTGAAATCTCACAGAGTTCTGAAGTGGAAG GCCGATAAATCTCTTTCTTATAACTCAAGGTTCTGGAAGAACCTTCTTTACTTAATGCCTGCAAAAACA GTCAAGCCAGGTAGAGACGAACCGGAAGTCTTGCCTGTTCTTTCCGAGTCTTAA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC
Restriction Sites	SgfI-MluI
ACCN	NM_001282399
Insert Size	1158 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001282399.1
RefSeq Size	3471 bp
RefSeq ORF	1158 bp
Locus ID	8809
UniProt ID	Q13478
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction
MW	44.2 kDa
Gene Summary	The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] Transcript Variant: This variant (2) lacks an exon in the 5' region but has an additional exon in a downstream region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.

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