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Caspase 5 (CASP5) (NM_004347) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC210421L3V
- LentiORF®
-
Lenti ORF particles, CASP5 (Myc-DDK tagged) - Human caspase 5, apoptosis-related cysteine peptidase (CASP5), transcript variant a, 200ul, >10^7 TU/mL
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CNY 8,740.00
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| Product Data | |
| Product Name | Caspase 5 (CASP5) (NM_004347) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | ICE(rel)III; ICEREL-III; ICH-3 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_004347 |
| ORF Size | 1254 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC210421).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_004347.1 |
| RefSeq Size | 1449 bp |
| RefSeq ORF | 1305 bp |
| Locus ID | 838 |
| Protein Families | Druggable Genome, Protease |
| Protein Pathways | NOD-like receptor signaling pathway |
| MW | 47.8 kDa |
| Gene Summary | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010] |
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