Human Apolipoprotein CI (APOC1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	APOC1
Locus ID	341
Kit Components	GA100241G1, Apolipoprotein CI gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100241G2, Apolipoprotein CI gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100241G3, Apolipoprotein CI gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001321065, NM_001321066, NM_001645
Synonyms	Apo-CI; apo-CIB; ApoC-I; apoC-IB
Summary	This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]

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