Human Arginase 1 (ARG1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ARG1
Locus ID	383
Kit Components	GA100275G1, Arginase 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100275G2, Arginase 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100275G3, Arginase 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000045, NM_001244438, NR_160934, NM_001369020
Synonyms	arginase, liver; arginase 1; liver-type arginase; OTTHUMP00000017209; type I arginase
Summary	Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

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