Human BCKDHB activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	BCKDHB
Locus ID	594
Kit Components	GA100408G1, BCKDHB gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100408G2, BCKDHB gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100408G3, BCKDHB gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000056, NM_001318975, NM_183050, NR_134945
Synonyms	BCKDE1B; BCKDH E1-beta; E1B
Summary	This gene encodes the E1 beta subunit of branched-chain keto acid dehydrogenase, which is a multienzyme complex associated with the inner membrane of mitochondria. This enzyme complex functions in the catabolism of branched-chain amino acids. Mutations in this gene have been associated with maple syrup urine disease (MSUD), type 1B, a disease characterized by a maple syrup odor to the urine in addition to mental and physical retardation and feeding problems. Alternative splicing at this locus results in multiple transcript variants. [provided by RefSeq, Jan 2016]

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