Human Caldesmon (CALD1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CALD1
Locus ID	800
Kit Components	GA100560G1, Caldesmon gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100560G2, Caldesmon gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100560G3, Caldesmon gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_004342, NM_018495, NM_033138, NM_033139, NM_033140, NM_033157
Synonyms	CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22
Summary	This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

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