Human Caspase 4 (CASP4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CASP4
Locus ID	837
Kit Components	GA100590G1, Caspase 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100590G2, Caspase 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100590G3, Caspase 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001225, NM_033306, NM_033307
Synonyms	ICE(rel)II; ICEREL-II; ICH-2; Mih1; Mih1/TX; TX
Summary	This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

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