Human CBFA2T3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CBFA2T3
Locus ID	863
Kit Components	GA100607G1, CBFA2T3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100607G2, CBFA2T3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100607G3, CBFA2T3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_005187, NM_175931
Synonyms	ETO2; MTG16; MTGR2; ZMYND4
Summary	This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

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