Human KRIT1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	KRIT1
Locus ID	889
Kit Components	GA100623G1, KRIT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100623G2, KRIT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100623G3, KRIT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001013406, NM_004912, NM_194454, NM_194455, NM_194456, NM_001350669, NM_001350670, NM_001350671, NM_001350672, NM_001350673, NM_001350674, NM_001350675, NM_001350676, NM_001350677, NM_001350678, NM_001350679, NM_001350680, NM_001350681, NM_001350682, NM_001350683, NM_001350684, NM_001350685, NM_001350686, NM_001350687, NM_001350688, NM_001350689, NM_001350690, NM_001350691, NM_001350692, NM_001350693, NM_001350694, NM_001350695, NM_001350696, NM_001350697
Synonyms	CAM; CCM1
Summary	This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

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