Human CHIT1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CHIT1
Locus ID	1118
Kit Components	GA100798G1, CHIT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100798G2, CHIT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100798G3, CHIT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001256125, NM_001270509, NM_003465, NR_045784, NR_045785
Synonyms	CHI3; CHIT; CHITD
Summary	Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]

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