Human Carboxypeptidase B2 (CPB2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CPB2
Locus ID	1361
Kit Components	GA100951G1, Carboxypeptidase B2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100951G2, Carboxypeptidase B2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100951G3, Carboxypeptidase B2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001278541, NM_001872, NM_016413
Synonyms	CPU; PCPB; TAFI
Summary	Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

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