Human Cellular Apoptosis Susceptibility (CSE1L) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CSE1L
Locus ID	1434
Kit Components	GA101008G1, Cellular Apoptosis Susceptibility gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101008G2, Cellular Apoptosis Susceptibility gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101008G3, Cellular Apoptosis Susceptibility gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001256135, NM_001316, NM_177436, NR_045796, NM_001362762
Synonyms	CAS; CSE1; XPO2
Summary	Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

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