Human CTNNA2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CTNNA2
Locus ID	1496
Kit Components	GA101058G1, CTNNA2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101058G2, CTNNA2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101058G3, CTNNA2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001164883, NM_001282597, NM_001282598, NM_001282599, NM_001282600, NM_004389, NM_001320810
Synonyms	CAP-R; CAPR; CT114; CTNR
Summary	May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).[UniProtKB/Swiss-Prot Function]

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