Human Lipoamide Dehydrogenase (DLD) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DLD
Locus ID	1738
Kit Components	GA101207G1, Lipoamide Dehydrogenase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101207G2, Lipoamide Dehydrogenase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101207G3, Lipoamide Dehydrogenase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000108, NM_001289750, NM_001289751, NM_001289752
Synonyms	DLDD; DLDH; E3; GCSL; LAD; PHE3
Summary	This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

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