Human DUSP1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DUSP1
Locus ID	1843
Kit Components	GA101293G1, DUSP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101293G2, DUSP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101293G3, DUSP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_004417
Synonyms	CL100; HVH1; MKP-1; MKP1; PTPN10
Summary	The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]

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