Human CD89 (FCAR) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	FCAR
Locus ID	2204
Kit Components	GA101542G1, CD89 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101542G2, CD89 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101542G3, CD89 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_002000, NM_133269, NM_133271, NM_133272, NM_133273, NM_133274, NM_133277, NM_133278, NM_133279, NM_133280
Synonyms	CD89; CTB-61M7.2; FcalphaRI
Summary	This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

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