Human GABA A Receptor alpha 4 (GABRA4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GABRA4
Locus ID	2557
Kit Components	GA101700G1, GABA A Receptor alpha 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101700G2, GABA A Receptor alpha 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101700G3, GABA A Receptor alpha 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000809, NM_001204266, NM_001204267
Synonyms	gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid A receptor, alpha 4
Summary	Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]

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