Human Neuronal membrane glycoprotein M6 a (GPM6A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GPM6A
Locus ID	2823
Kit Components	GA101888G1, Neuronal membrane glycoprotein M6 a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101888G2, Neuronal membrane glycoprotein M6 a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101888G3, Neuronal membrane glycoprotein M6 a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001261447, NM_001261448, NM_005277, NM_201591, NM_201592, NR_048571
Synonyms	GPM6; M6A
Summary	Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.[UniProtKB/Swiss-Prot Function]

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