Human Metabotropic Glutamate Receptor 8 (GRM8) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GRM8
Locus ID	2918
Kit Components	GA101973G1, Metabotropic Glutamate Receptor 8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101973G2, Metabotropic Glutamate Receptor 8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101973G3, Metabotropic Glutamate Receptor 8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000845, NM_001127323, NM_001127326, NR_028041
Synonyms	GLUR8; GPRC1H; mGlu8; MGLUR8
Summary	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

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