Human GUCY1B1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GUCY1B1
Locus ID	2983
Kit Components	GA102024G1, GUCY1B1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102024G2, GUCY1B1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102024G3, GUCY1B1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000857, NM_001291951, NM_001291952, NM_001291953, NM_001291954, NM_001291955
Synonyms	GC-S-beta-1; GC-SB3; GUC1B3; GUCB3; GUCSB3; GUCY1B1
Summary	This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

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