Human HINT1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HINT1
Locus ID	3094
Kit Components	GA102110G1, HINT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102110G2, HINT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102110G3, HINT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_005340, NR_024610, NR_024611, NR_073488, NR_134494, NR_134495
Synonyms	HINT; NMAN; PKCI-1; PRKCNH1
Summary	This gene encodes a protein that hydrolyzes purine nucleotide phosphoramidates substrates, including AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif. This gene is considered a tumor suppressor gene. In addition, mutations in this gene can cause autosomal recessive neuromyotonia and axonal neuropathy. There are several related pseudogenes on chromosome 7. Several transcript variants have been observed. [provided by RefSeq, Dec 2015]

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