Human HMBS activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HMBS
Locus ID	3145
Kit Components	GA102144G1, HMBS gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102144G2, HMBS gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102144G3, HMBS gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000190, NM_001024382, NM_001258208, NM_001258209
Synonyms	PBG-D; PBGD; PORC; UPS
Summary	This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

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