Human PRMT2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PRMT2
Locus ID	3275
Kit Components	GA102239G1, PRMT2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102239G2, PRMT2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102239G3, PRMT2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001242864, NM_001242865, NM_001242866, NM_001286676, NM_001286677, NM_001286678, NM_001535, NM_206962
Synonyms	HRMT1L1
Summary	Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.[UniProtKB/Swiss-Prot Function]

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