Human Hydroxysteroid (17 beta) Dehydrogenase 4 (HSD17B4) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HSD17B4
Locus ID	3295
Kit Components	GA102250G1, Hydroxysteroid (17 beta) Dehydrogenase 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102250G2, Hydroxysteroid (17 beta) Dehydrogenase 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102250G3, Hydroxysteroid (17 beta) Dehydrogenase 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000414, NM_001199291, NM_001199292, NM_001292027, NM_001292028
Synonyms	DBP; MFE-2; MPF-2; PRLTS1; SDR8C1
Summary	The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

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