Human IRF8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	IRF8
Locus ID	3394
Kit Components	GA102303G1, IRF8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102303G2, IRF8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102303G3, IRF8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_002163, NM_001363907, NM_001363908
Synonyms	H-ICSBP; ICSBP; ICSBP1; IMD32A; IMD32B; IRF-8
Summary	Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]

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