Human IGF1 Receptor (IGF1R) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	IGF1R
Locus ID	3480
Kit Components	GA102349G1, IGF1 Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102349G2, IGF1 Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102349G3, IGF1 Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000875, NM_001291858
Synonyms	CD221; IGFIR; IGFR; JTK13
Summary	This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

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