Human IGF2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	IGF2
Locus ID	3481
Kit Components	GA102350G1, IGF2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102350G2, IGF2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102350G3, IGF2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000612, NM_001007139, NM_001127598, NM_001291861, NM_001291862
Synonyms	C11orf43; GRDF; IGF-II; PP9974
Summary	This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

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