Human IMPDH1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	IMPDH1
Locus ID	3614
Kit Components	GA102420G1, IMPDH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102420G2, IMPDH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102420G3, IMPDH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000883, NM_001102605, NM_001142573, NM_001142574, NM_001142575, NM_001142576, NM_001304521, NM_183243
Synonyms	IMPD; IMPD1; LCA11; RP10; sWSS2608
Summary	The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

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