Human Lactate Dehydrogenase B (LDHB) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LDHB
Locus ID	3945
Kit Components	GA102673G1, Lactate Dehydrogenase B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102673G2, Lactate Dehydrogenase B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102673G3, Lactate Dehydrogenase B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001174097, NM_002300, NM_001315537
Synonyms	HEL-S-281; LDH-B; LDH-H; LDHBD; TRG-5
Summary	This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]

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