Human MADH7 (SMAD7) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SMAD7
Locus ID	4092
Kit Components	GA102780G1, MADH7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102780G2, MADH7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102780G3, MADH7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001190821, NM_001190822, NM_001190823, NM_005904
Synonyms	CRCS3; MADH7; MADH8
Summary	The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

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