Human Mineralocorticoid Receptor (NR3C2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NR3C2
Locus ID	4306
Kit Components	GA102930G1, Mineralocorticoid Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102930G2, Mineralocorticoid Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102930G3, Mineralocorticoid Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000901, NM_001166104, NM_001354819, NR_148974
Synonyms	MCR; MLR; MR; NR3C2VIT
Summary	This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

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