Human NEDD4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NEDD4
Locus ID	4734
Kit Components	GA103159G1, NEDD4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103159G2, NEDD4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103159G3, NEDD4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001284338, NM_001284339, NM_001284340, NM_006154, NM_198400, NR_104302, NM_001329212
Synonyms	NEDD4-1; RPF1
Summary	This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]

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