Human NPAT activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NPAT
Locus ID	4863
Kit Components	GA103249G1, NPAT gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103249G2, NPAT gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103249G3, NPAT gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_002519, NM_001321307
Synonyms	E14; E14/NPAT; p220
Summary	Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters.[UniProtKB/Swiss-Prot Function]

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