Human PDE4A activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PDE4A
Locus ID	5141
Kit Components	GA103438G1, PDE4A gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103438G2, PDE4A gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103438G3, PDE4A gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001111307, NM_001111308, NM_001111309, NM_001243121, NM_006202
Synonyms	DPDE2; PDE4; PDE46
Summary	The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

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