Human PLCL1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PLCL1
Locus ID	5334
Kit Components	GA103594G1, PLCL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103594G2, PLCL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103594G3, PLCL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001114661, NM_006226
Synonyms	MGC126580; MGC138190; OTTHUMP00000163640; phospholipase C, epsilon; phospholipase C-like 1; PLC-L; PLCE; PLCL; PLDL1
Summary	Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.[UniProtKB/Swiss-Prot Function]

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