Human POLR2E activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	POLR2E
Locus ID	5434
Kit Components	GA103657G1, POLR2E gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103657G2, POLR2E gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103657G3, POLR2E gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001316323, NM_001316324, NM_002695
Synonyms	hRPB25; hsRPB5; RPABC1; RPB5; XAP4
Summary	This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

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