Human Papillary renal cell carcinoma (PRCC) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PRCC
Locus ID	5546
Kit Components	GA103743G1, Papillary renal cell carcinoma gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103743G2, Papillary renal cell carcinoma gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103743G3, Papillary renal cell carcinoma gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_005973, NM_199416
Synonyms	RCCP1; TPRC
Summary	This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]

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