Human PTPRN2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PTPRN2
Locus ID	5799
Kit Components	GA103943G1, PTPRN2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103943G2, PTPRN2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103943G3, PTPRN2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001308267, NM_001308268, NM_002847, NM_130842, NM_130843
Synonyms	IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2
Summary	This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

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