Human Germinal Center Kinase (MAP4K2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MAP4K2
Locus ID	5871
Kit Components	GA103985G1, Germinal Center Kinase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103985G2, Germinal Center Kinase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103985G3, Germinal Center Kinase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001307990, NM_004579
Synonyms	BL44; GCK; RAB8IP
Summary	The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

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